| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Growth arrest specific 6 ameliorated inflammation and portal pressure through activating efferocytosis in cholestasis and portal hypertension
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Gu-Qing Luo, Jin-Bo Zhao, Zheng-Hao Wu, Jia-Yun Lin, Chi-Hao Zhang, Guang-Bo Wu, Qiang Fan, Xiao-Liang Qi, Hong-Jie Li, Meng Luo and Lei Zheng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Postdoctoral Scientific Research Foundation of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine |
202401023 |
| Shanghai Municipal Commission of Health and Family Planning |
20244Y0195 |
| Shanghai Municipal Commission of Health and Family Planning |
20234Y0132 |
| National Natural Science Foundation of China |
82100639 |
| National Natural Science Foundation of China |
82200630 |
| National Natural Science Foundation of China |
81970526 |
|
| Corresponding Author |
Lei Zheng, MD, PhD, Department of General Surgery, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Jiao Tong University, No. 639 Zhizaoju Road, Huangpu District, Shanghai 200011, China. zl1055174020@163.com |
| Key Words |
Portal hypertension; Cholestatic liver disease; Growth arrest specific 6; Efferocytosis; MER proto-oncogene; Tyrosine kinase |
| Core Tip |
The current study revealed that defective efferocytosis was related to portal hypertension (PHT) in mice model of cholestasis. Administration of recombinant growth arrest specific 6 (Gas6) ameliorated elevated intrahepatic vascular resistance and portal pressure in cholestasis. Gas6 enhanced macrophage efferocytosis by activating MerTK, which relieved inflammation and eventually alleviated liver sinusoidal endothelial cell dysfunction and PHT. |
| Publish Date |
2026-05-20 08:22 |
| Citation |
Luo GQ, Zhao JB, Wu ZH, Lin JY, Zhang CH, Wu GB, Fan Q, Qi XL, Li HJ, Luo M, Zheng L. Growth arrest specific 6 ameliorated inflammation and portal pressure through activating efferocytosis in cholestasis and portal hypertension. World J Gastroenterol 2026; 32(20): 116020 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i20/116020.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i20.116020 |
