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Articles Published Processes
4/10/2026 7:08:44 AM | Browse: 3 | Download: 7
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Received |
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2025-11-03 08:05 |
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Peer-Review Started |
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2025-11-03 08:07 |
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First Decision by Editorial Office Director |
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2025-11-10 07:04 |
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Return for Revision |
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2025-11-10 07:04 |
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Revised |
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2025-11-17 13:39 |
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Publication Fee Transferred |
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2025-11-18 10:13 |
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Second Decision by Editor |
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2026-01-09 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-09 14:12 |
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Articles in Press |
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2026-01-09 14:12 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-30 09:44 |
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Publish the Manuscript Online |
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2026-04-10 07:08 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ao-Xue Yu, Wei-Hui Liang, Ya-Shuang Zhou, Pan Li, Jia-Mei Ji, Feng-Wei Zhang, Peng Yu and Jia Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Science and Technology Department of Jilin Province - Jilin Provincial Science and Technology Development Plan Project |
20250204060YY |
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| Corresponding Author |
Jia Liu, PhD, Office of Scientific Research, Changchun University of Chinese Medicine, No. 1035 Boshuo Road, Jingyue National High-tech Industrial Development Zone, Changchun 130117, Jilin Province, China. ccliujia1002@126.com |
| Key Words |
Osteoporosis; Xianling Gubao capsule; Gut microbiota; Ovariectomized rats; Wnt/β-catenin |
| Core Tip |
This study demonstrates that the Xianling Gubao capsule (XLGB) alleviates osteoporosis by modulating the gut-bone axis. Utilizing a multi-omics approach, we reveal that XLGB not only improves bone microstructure and serum bone markers but also rectifies ovariectomy-induced gut microbiota dysbiosis and metabolic disturbances. More importantly, we identify that its core mechanism involves the activation of the osteogenic Wnt/β-catenin pathway while simultaneously suppressing the adipogenic peroxisome proliferator-activated receptor gamma pathway, thereby rebalancing osteogenic-adipogenic differentiation in the bone marrow. This provides a novel mechanistic basis for XLGB’s anti-osteoporotic effects and underscores the gut-bone axis as a promising therapeutic target. |
| Publish Date |
2026-04-10 07:08 |
| Citation |
Yu AX, Liang WH, Zhou YS, Li P, Ji JM, Zhang FW, Yu P, Liu J. Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling. World J Orthop 2026; 17(4): 116046 |
| URL |
https://www.wjgnet.com/2218-5836/full/v17/i4/116046.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v17.i4.116046 |
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