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Articles Published Processes
5/11/2026 9:00:18 AM | Browse: 5 | Download: 15
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Received |
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2025-11-02 11:09 |
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Peer-Review Started |
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2025-11-07 00:39 |
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First Decision by Editorial Office Director |
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2025-11-28 07:53 |
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Return for Revision |
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2025-11-28 07:53 |
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Revised |
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2025-12-12 02:09 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-13 00:18 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-30 04:13 |
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Articles in Press |
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2026-01-30 04:13 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-28 12:33 |
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Publish the Manuscript Online |
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2026-05-11 09:00 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Association between high waist-height ratio and endoplasmic reticulum stress of young adults with insulin resistance
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Oscar E Casillas, César A Hernández-Aguirre, Ana Gabriela Leija-Montoya, Tatiana Romero-García and J Gustavo Vázquez-Jiménez |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Program of Universidad Autónoma de Baja California |
106/2/C/27/25 |
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| Corresponding Author |
J Gustavo Vázquez-Jiménez, MD, PhD, Departamento de Fisiología, Facultad de Medicina y Nutrición, Universidad Autónoma de Baja California, Centro Cívico, Mexicali 21000, Baja California, Mexico. gustavo.vazquez@uabc.edu.mx |
| Key Words |
Endoplasmic reticulum stress; Insulin resistance; Waist-to-height ratio; Unfolded protein response; Adiposity |
| Core Tip |
Insulin resistance (IR), a health complication commonly associated with advanced age, is increasingly affecting the young population due to poor eating habits and a sedentary lifestyle. In this study, conducted with 39 young adults, participants with a waist-to-height ratio greater than 0.5 showed elevated insulin levels, higher Homeostatic Model Assessment of Insulin Resistance, and altered body composition. Likewise, these participants exhibited platelet molecular disturbances, including IR and activation of proteins associated with endoplasmic reticulum stress. The results suggest that excessive central adiposity in the young population triggers early activation of molecular mechanisms underlying the development of metabolic diseases, such as type 2 diabetes mellitus. |
| Publish Date |
2026-05-11 09:00 |
| Citation |
Casillas OE, Hernández-Aguirre CA, Leija-Montoya AG, Romero-García T, Vázquez-Jiménez JG. Association between high waist-height ratio and endoplasmic reticulum stress of young adults with insulin resistance. World J Diabetes 2026; 17(5): 116053 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i5/116053.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i5.116053 |
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