| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Letter to the Editor |
| Article Title |
DCPS as a promising biomarker in diabetic foot ulcers: A need for cautious interpretation
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiao-Ling Huang, Ying Wang, De-Fang Chen, Jin-Nian Duan, Ntim Michael, Rong Jiang, Yu-Song Ge and Bin Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Shandong Province |
ZR2022QH087 |
| General Program of the Joint Fund Project under the Liaoning Provincial Science and Technology Plan |
2024-MSLH-104 |
|
| Corresponding Author |
Bin Wang, Liaoning Provincial Key Laboratory of Cerebral Diseases, College of Basic Medical Sciences, National-Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases, Dalian Medical University, Liaoning Provincial Key Laboratory of Cerebral Diseases, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liasonaing, China. Electronic address: wb101900@126.com, Dalian 116000, Liaoning Province, China. wb101900@126.com |
| Key Words |
Diabetic foot ulcer; Decapping scavenger enzyme; RNA methylation; Biomarker; Keratinocyte proliferation; Wound healing |
| Core Tip |
Decapping scavenger enzyme(DCPS), an N7-methylguanosine (m7G)-related gene, has emerged as a potential diagnostic and therapeutic biomarker for diabetic foot ulcer (DFU) by linking RNA methylation to impaired keratinocyte function and wound repair. However, its variable expression, lack of standardized reference ranges, and uncertain therapeutic efficacy necessitate further validation. Future research should clarify DCPS’s regulatory mechanisms, develop clinical quantification standards, and assess targeted modulation to enhance its diagnostic precision and therapeutic potential in DFU. |
| Publish Date |
2026-02-06 08:43 |
| Citation |
Huang XL, Wang Y, Chen DF, Duan JN, Michael N, Jiang R, Ge YS, Wang B. DCPS as a promising biomarker in diabetic foot ulcers: A need for cautious interpretation. World J Diabetes 2026; 17(2): 116056 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i2/116056.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i2.116056 |
