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Articles Published Processes
4/21/2026 8:57:44 AM | Browse: 12 | Download: 20
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Received |
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2025-11-02 13:19 |
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Peer-Review Started |
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2025-11-02 13:19 |
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First Decision by Editorial Office Director |
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2025-12-12 08:41 |
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Return for Revision |
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2025-12-12 08:41 |
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Revised |
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2025-12-29 13:35 |
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Publication Fee Transferred |
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2026-01-08 14:26 |
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Second Decision by Editor |
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2026-01-27 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-27 06:45 |
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Articles in Press |
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2026-01-27 06:45 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-10 00:37 |
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Publish the Manuscript Online |
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2026-04-21 08:57 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
High-fat diet, gut dysbiosis, and oxidative stress: A synergistic triangle in metabolic dysfunction-associated steatotic liver disease pathogenesis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Rui Zhang, Ling She, Yi-Rong Cao and Yuan-Wen Chen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Nature Science Foundation of China |
No. 82270620 |
| Key Department Project of Huadong Hospital |
No. ZDXK2213 |
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| Corresponding Author |
Yuan-Wen Chen, MD, PhD, Department of Gastroenterology, Huadong Hospital, Fudan University, No. 221 West Yan’an Road, Shanghai 200000, China. chenywhdgi@fudan.edu.cn |
| Key Words |
Metabolic dysfunction-associated steatotic liver disease; High-fat diet; Gut dysbiosis; Oxidative stress; Intestinal barrier dysfunction |
| Core Tip |
This review proposes a unifying framework in which a high-fat diet, gut dysbiosis, and oxidative stress form a self-reinforcing pathogenic triad driving metabolic dysfunction-associated steatotic liver disease. We synthesize evidence showing how diet-induced microbial imbalance disrupts intestinal barrier integrity, promotes endotoxemia, and amplifies hepatic oxidative stress, mitochondrial dysfunction, inflammation, and fibrosis. By positioning oxidative stress as a central mechanistic nexus linking diet and microbiota, this review highlights antioxidant-based lifestyle, nutritional, and pharmacological strategies as promising, integrative approaches for prevention and treatment. |
| Publish Date |
2026-04-21 08:57 |
| Citation |
Zhang ZR, She L, Cao YR, Chen YW. High-fat diet, gut dysbiosis, and oxidative stress: A synergistic triangle in metabolic dysfunction-associated steatotic liver disease pathogenesis. World J Hepatol 2026; 18(4): 116074 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i4/116074.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i4.116074 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
