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Articles Published Processes
1/20/2026 9:06:34 AM | Browse: 1 | Download: 0
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Received |
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2025-11-02 11:22 |
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Peer-Review Started |
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2025-11-02 11:22 |
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First Decision by Editorial Office Director |
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2025-11-26 09:07 |
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Return for Revision |
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2025-11-26 09:07 |
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Revised |
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2025-11-26 14:49 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-29 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-29 10:01 |
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Articles in Press |
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2025-12-29 10:01 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-07 09:24 |
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Publish the Manuscript Online |
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2026-01-20 09:06 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Beyond sensitivity and specificity: Redefining the era connotation of “low-risk” in pancreatic cancer screening
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rui-Gang Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Tsinghua Changgung Hospital Youth Fund |
12021C1011 |
| the Capital Medical Science and Technology Innovation Achievement Transformation Optimization Promotion Plan |
YC202501QX0920 |
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| Corresponding Author |
Rui-Gang Wang, MD, Department of Gastroenterology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, No. 168 Litang Road, Changping District, Beijing 102218, China. doctorwrg@163.com |
| Key Words |
Pancreatic cancer screening; Low-risk redefinition; Dynamic risk stratification; Precision prevention; Multimodal integration |
| Core Tip |
This commentary argues that the conventional "low-risk" label for pancreatic cancer (PC), based solely on family history and known genetic syndromes, is obsolete. We propose a paradigm shift towards a dynamic, multidimensional risk model. This framework continuously integrates polygenic risk scores (PRS), liquid biopsy biomarkers (e.g., circulating tumor DNA), lifestyle factors, and artificial intelligence to enable real-time, personalized risk stratification. This approach can reclassify a significant portion of the "low-risk" population, paving the way for precision screening and potentially transforming early detection strategies for this lethal malignancy. |
| Publish Date |
2026-01-20 09:06 |
| Citation |
Wang RG. Beyond sensitivity and specificity: Redefining the era connotation of “low-risk” in pancreatic cancer screening. World J Clin Oncol 2026; 17(1): 116090 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i1/116090.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i1.116090 |
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