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Publication Name World Journal of Clinical Oncology
Manuscript ID 116093
Country United States
Received
2025-11-02 11:47
Peer-Review Started
2025-11-03 00:41
First Decision by Editorial Office Director
2025-11-26 09:31
Return for Revision
2025-11-26 09:31
Revised
2026-01-02 00:39
Publication Fee Transferred
Second Decision by Editor
2026-02-09 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-09 09:00
Articles in Press
2026-02-09 09:00
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-03-12 00:35
Publish the Manuscript Online
2026-03-23 08:21
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Immunotherapy in liver metastases: Challenges, emerging evidence, and future directions
Manuscript Source Invited Manuscript
All Author List Hoang Tran Pham, Zhong-Yi Dong, Margarita De Alba, Chasen Cottle, Ming-Yi Zhang, Joseph B Parker, Renee Morecroft-Phillipps, Keyur Chaludiya, Demarcus Ingram, Ayesha N Ahmad, Zhen Zeng, Michael M Mohseni, Zi-Zhen Zhang, Libardo Rueda Prada, Muhammad Ali and Vivienne Yang
ORCID
Author(s) ORCID Number
Zhong-Yi Dong http://orcid.org/0009-0004-4613-6787
Vivienne Yang http://orcid.org/0009-0008-8840-6676
Funding Agency and Grant Number
Corresponding Author Vivienne Yang, MD, PhD, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL 32224, United States. vivienne.yang@proton.me
Key Words Liver metastasis; Tumor microenvironment; Immune crosstalk; Cancer immunotherapy; Translational oncology
Core Tip This review highlights how the liver’s unique vascular and immune environment fosters metastasis. We summarize key cellular interactions, the concept of the hepatic pre-metastatic niche, and emerging therapeutic strategies that may improve outcomes for patients with liver metastases.
Publish Date 2026-03-23 08:21
Citation

Pham HT, Dong ZY, De Alba M, Cottle C, Zhang MY, Parker JB, Morecroft-Phillipps R, Chaludiya K, Ingram D, Ahmad AN, Zeng Z, Mohseni MM, Zhang ZZ, Rueda Prada L, Ali M, Yang V. Immunotherapy in liver metastases: Challenges, emerging evidence, and future directions. World J Clin Oncol 2026; 17(3): 116093

URL https://www.wjgnet.com/2218-4333/full/v17/i3/116093.htm
DOI https://dx.doi.org/10.5306/wjco.v17.i3.116093
Full Article (PDF) WJCO-17-116093-with-cover.pdf
Manuscript File 116093_Auto_Edited_060604.docx
Answering Reviewers 116093-answering-reviewers.pdf
Audio Core Tip 116093-audio.mp3
Conflict-of-Interest Disclosure Form 116093-conflict-of-interest-statement.pdf
Copyright License Agreement 116093-copyright-assignment.pdf
Peer-review Report 116093-peer-reviews.pdf
Scientific Misconduct Check 116093-scientific-misconduct-check.png
Scientific Editor Work List 116093-scientific-editor-work-list.pdf
CrossCheck Report 116093-crosscheck-report.pdf