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Articles Published Processes
4/8/2026 7:28:49 AM | Browse: 0 | Download: 0
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Received |
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2025-11-03 06:57 |
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Peer-Review Started |
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2025-11-03 06:57 |
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First Decision by Editorial Office Director |
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2025-11-14 09:30 |
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Return for Revision |
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2025-11-15 15:31 |
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Revised |
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2025-11-19 07:10 |
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Publication Fee Transferred |
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2025-11-21 03:39 |
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Second Decision by Editor |
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2026-01-04 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-04 14:36 |
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Articles in Press |
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2026-01-04 14:36 |
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Edit the Manuscript by Language Editor |
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2026-01-09 00:10 |
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Typeset the Manuscript |
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2026-03-27 01:42 |
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Publish the Manuscript Online |
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2026-04-08 07:28 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
MicroRNA-206 suppresses hypoxia-inducible factor-1α/PFKFB3-mediated glycolysis to inhibit recurrence and metastasis of hepatocellular carcinoma after incomplete radiofrequency ablation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dong Lu, Li-Jun Wang, Jie Chai, Jun Jiang and Yan-Lin Tang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Project Supported by Anhui Health and Scientific Research Foundation |
AHWJ2024Aa10119 |
| Key Research and Development Projects of Anhui Province |
201904a07020091 |
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| Corresponding Author |
Dong Lu, MD, PhD, Department of Interventional Radiology, The Second Affiliated Hospital of Anhui Medical University, No. 678 Furong Road, Hefei 230601, Anhui Province, China. hyjh2004@126.com |
| Key Words |
MicroRNA-206; Hypoxia-inducible factor-1α; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; Glycolysis; Incomplete radiofrequency ablation; Hepatocellular carcinoma; Tumor recurrence; Angiogenesis |
| Core Tip |
Incomplete radiofrequency ablation (iRFA) creates a hypoxic microenvironment that drives hepatocellular carcinoma recurrence. This study reveals that microRNA-206 (miR-206) directly targets hypoxia-inducible factor-1α and suppresses PFKFB3-mediated glycolysis, thereby reducing angiogenesis, migration, and metastasis after iRFA. Using patient samples, endothelial cell models, and a rabbit VX2 tumor model, we demonstrate that restoring miR-206 expression counteracts post-ablation metabolic reprogramming. These findings highlight miR-206 as a promising therapeutic target to prevent recurrence and improve long-term outcomes after local ablation therapy in hepatocellular carcinoma. |
| Publish Date |
2026-04-08 07:28 |
| Citation |
Lu D, Wang LJ, Chai J, Jiang J, Tang YL. MicroRNA-206 suppresses hypoxia-inducible factor-1α/PFKFB3-mediated glycolysis to inhibit recurrence and metastasis of hepatocellular carcinoma after incomplete radiofrequency ablation. World J Gastrointest Oncol 2026; 18(4): 116104 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i4/116104.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i4.116104 |
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