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Publication Name World Journal of Gastroenterology
Manuscript ID 116121
Country China
Received
2025-11-03 04:31
Peer-Review Started
2025-11-03 04:31
First Decision by Editorial Office Director
2025-12-04 09:24
Return for Revision
2025-12-04 09:24
Revised
2025-12-10 09:22
Publication Fee Transferred
Second Decision by Editor
2026-01-13 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-13 04:32
Articles in Press
2026-01-13 04:32
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-03-03 03:59
Publish the Manuscript Online
2026-04-15 06:47
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Correspondence
Article Title Letter to the Editor: Balancing efficacy and toxicity: The critical role of predictive models in colorectal cancer chemotherapy
Manuscript Source Invited Manuscript
All Author List Yi-Wei Qin, Peng-Wei Li, Xin-Yi Liang, You Mo and Da-Wei Chen
ORCID
Author(s) ORCID Number
You Mo http://orcid.org/0000-0001-5283-0741
Da-Wei Chen http://orcid.org/0000-0002-6762-7997
Funding Agency and Grant Number
Corresponding Author Da-Wei Chen, MD, Professor, Researcher, Cancer Hospital of Shandong First Medical University (Shandong Cancer Institute, Shandong Cancer Hospital), No. 440 Jiyan Road, Jinan 250000, Shandong Province, China. dave0505@yeah.net
Key Words Clinic-machine learning nomogram; Efficacy; Toxicity; Colorectal cancer; Chemotherapy
Core Tip We propose expanding Liu et al’s interpretable machine learning-based nomogram beyond myelosuppression to an integrated efficacy-toxicity platform that simultaneously forecasts tumor response and common multi-organ adverse events. By embedding these dual predictions into a real-time, utility-based clinical decision support system, designed for practical clinical use, clinicians can instantly identify the regimen offering each patient the maximal therapeutic index, thereby optimizing personalized treatment decisions.
Publish Date 2026-04-15 06:47
Citation

Qin YW, Li PW, Liang XY, Mo Y, Chen DW. Letter to the Editor: Balancing efficacy and toxicity: The critical role of predictive models in colorectal cancer chemotherapy. World J Gastroenterol 2026; 32(15): 116121

URL https://www.wjgnet.com/1007-9327/full/v32/i15/116121.htm
DOI https://dx.doi.org/10.3748/wjg.v32.i15.116121
Full Article (PDF) WJG-32-116121-with-cover.pdf
Manuscript File 116121_Auto_Edited_010559.docx
Answering Reviewers 116121-answering-reviewers.pdf
Audio Core Tip 116121-audio.mp3
Conflict-of-Interest Disclosure Form 116121-conflict-of-interest-statement.pdf
Copyright License Agreement 116121-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 116121-non-native-speakers.pdf
Peer-review Report 116121-peer-reviews.pdf
Scientific Misconduct Check 116121-scientific-misconduct-check.png
Scientific Editor Work List 116121-scientific-editor-work-list.pdf
CrossCheck Report 116121-crosscheck-report.pdf