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Articles Published Processes
7/17/2026 8:23:31 AM | Browse: 4 | Download: 0
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Received |
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2025-11-03 04:29 |
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Peer-Review Started |
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2025-11-03 04:29 |
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First Decision by Editorial Office Director |
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2025-12-29 09:24 |
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Return for Revision |
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2025-12-29 09:24 |
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Revised |
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2026-01-07 03:17 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-26 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-26 11:10 |
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Articles in Press |
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2026-02-26 11:10 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-13 01:05 |
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Publish the Manuscript Online |
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2026-07-17 08:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Correspondence |
| Article Title |
Letter to the Editor: From colorectal to pan-gastrointestinal cancer: Unlocking the therapeutic potential of DNA polymerase epsilon mutations
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ling-Feng Zou, Sui-Qi Yang, Shao-Ding Yu and Cheng-Long Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chongqing Health Commission and Science and Technology Bureau |
2023MSXM060 |
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| Corresponding Author |
Cheng-Long Wang, MD, PhD, Department of Pathology, Chongqing Traditional Chinese Medicine Hospital, No. 6 Panxi 7 branch Road, Jiangbei District, Chongqing 400021, China. qq171909771@gmail.com |
| Key Words |
DNA polymerase epsilon; Pan-gastrointestinal cancer; Immune checkpoint inhibitors; Tumor mutational burden; Biomarker; Mismatch repair deficiency |
| Core Tip |
To maximize the identification of immunotherapy candidates in gastrointestinal cancer, we advocate for a paradigm of concurrent mismatch repair and DNA polymerase epsilon testing. This dual strategy provides a crucial second pathway to therapy for patients with proficient mismatch repair tumors who harbor pathogenic DNA polymerase epsilon mutations, ensuring these “hidden hot tumors” are not overlooked by conventional screening. |
| Publish Date |
2026-07-17 08:23 |
| Citation |
Zou LF, Yang SQ, Yu SD, Wang CL. Letter to the Editor: From colorectal to pan-gastrointestinal cancer: Unlocking the therapeutic potential of DNA polymerase epsilon mutations. World J Gastroenterol 2026; 32(29): 116126
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i29/116126.htm |
| DOI |
https://doi.org/10.3748/wjg.116126 |
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