| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Targeting Dialister-driven succinate accumulation: A novel strategy for Crohn’s disease activity control and recurrence prevention
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Sheng Xu, Zheng Zhu, Hui-Ming Zhang, Yue-Ting Xu, Pei-Hong Shi, Yang Zheng, Yi-Tong Chen, Guang-Rong Lu and Bin-Jiao Zheng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhejiang Province Medical and Health Science and Technology Plan Project |
2024KY1239 |
| Wenzhou Science and Technology Plan Project |
Y2023107 |
| Talent Launch Project of Wenzhou Medical University |
KYYW202434 |
|
| Corresponding Author |
Bin-Jiao Zheng, PhD, Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, University Town, Chashan, Wenzhou 325000, Zhejiang Province, China. gusdy13x@wmu.edu.cn |
| Key Words |
Crohn’s disease; Succinate; Therapeutic targets; Gut microbiota; Inflammatory bowel disease; Postoperative recurrence; Dialister |
| Core Tip |
Crohn’s disease (CD) greatly affects patients’ quality of life, necessitating new treatment strategies. Boronat-Toscano et al examined the role of Dialister and succinate in CD by analyzing the fecal microbiota, circulating succinate levels, and clinical indices. They found that high succinate levels are linked to active CD and inflammation, with Dialister enrichment related to impaired succinate clearance and recurrence. These findings highlight succinate and Dialister as therapeutic targets, enhancing understanding of CD and guiding future research. Larger studies should validate these results, explore Dialister’s metabolic mechanisms, and develop treatments targeting the “succinate axis” to link basic research to clinical practice. |
| Publish Date |
2026-02-11 07:19 |
| Citation |
Xu S, Zhu Z, Zhang HM, Xu YT, Shi PH, Zheng Y, Chen YT, Lu GR, Zheng BJ. Targeting Dialister-driven succinate accumulation: A novel strategy for Crohn’s disease activity control and recurrence prevention. World J Gastroenterol 2026; 32(8): 116173 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i8/116173.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i8.116173 |
