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Articles Published Processes
4/20/2026 8:05:34 AM | Browse: 0 | Download: 0
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Received |
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2025-11-05 08:15 |
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Peer-Review Started |
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2025-11-05 08:15 |
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First Decision by Editorial Office Director |
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2025-11-25 07:46 |
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Return for Revision |
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2025-11-25 07:46 |
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Revised |
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2025-12-09 05:02 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-03 02:49 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-11 10:24 |
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Articles in Press |
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2026-02-11 10:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-31 09:25 |
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Publish the Manuscript Online |
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2026-04-20 08:05 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Basic Study |
| Article Title |
Adipose-derived stem cell stimulation using poly-L-lactic acid injection
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Raheel Arshad Zubair, Xi-Han Zhou and Sabrina Guillen Fabi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| an unrestricted educational grant from Galderma Laboratories; Fort Worth, TX, United States |
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| Corresponding Author |
Raheel Arshad Zubair, MD, Department of Research, Cosmetic Laser Dermatology, 9339 Genesee Avenue, Suite 300, San Diego, CA 92121, United States. raheel.zubair@platinumderm.com |
| Key Words |
Poly-L-lactic acid; Macrophage polarization; Adipose-derived stem cells; Aging; Biomaterials; Biostimulatory agents |
| Core Tip |
This study provides the first in vivo evidence that poly-L-lactic acid stimulates proliferation of cells expressing adipose-derived stem cell phenotype in human subcutaneous tissue. Using multiplex immunofluorescence on archived biopsy samples from a previous randomized clinical trial, poly-L-lactic acid-treated sites demonstrated marked expansion of cells exhibiting adipose-derived stem cell phenotype and fibroblasts in addition to a predominance of M2 macrophages consistent with a remodeling response. Most importantly, this may represent a novel regenerative paradigm using a minimally invasive technique. |
| Publish Date |
2026-04-20 08:05 |
| Citation |
Zubair RA, Zhou XH, Fabi SG. Adipose-derived stem cell stimulation using poly-L-lactic acid injection. World J Stem Cells 2026; 18(4): 116175 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i4/116175.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i4.116175 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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