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4/21/2026 8:57:45 AM | Browse: 2 | Download: 15
Publication Name World Journal of Hepatology
Manuscript ID 116176
Country United States
Received
2025-11-05 07:17
Peer-Review Started
2025-11-05 07:17
First Decision by Editorial Office Director
2025-11-25 07:54
Return for Revision
2025-11-25 07:54
Revised
2025-12-09 00:08
Publication Fee Transferred
Second Decision by Editor
2026-01-20 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-20 08:29
Articles in Press
2026-01-20 08:29
Edit the Manuscript by Language Editor
2026-01-30 00:35
Typeset the Manuscript
2026-04-10 08:12
Publish the Manuscript Online
2026-04-21 08:57
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Surgery
Manuscript Type Retrospective Study
Article Title In-hospital mortality and dynamic modified end-stage liver disease score after emergency general surgery in patients with cirrhosis
Manuscript Source Unsolicited Manuscript
All Author List Ashling L Zhang, Nathnael Tessema, Jaclyn Clark, Roumen Vesselinov, Lindsay O’Meara, David T Efron and Mira H Ghneim
ORCID
Author(s) ORCID Number
Ashling L Zhang http://orcid.org/0009-0007-8134-0398
Roumen Vesselinov http://orcid.org/0000-0001-9843-1586
Lindsay O’Meara http://orcid.org/0000-0003-1283-5315
David T Efron http://orcid.org/0009-0003-1136-7238
Mira H Ghneim http://orcid.org/0000-0001-5129-1520
Funding Agency and Grant Number
Corresponding Author Mira H Ghneim, Associate Professor, FACS, MD, Program in Trauma, University of Maryland School of Medicine, R. Adams Cowley Shock Trauma Center, 22 S. Greene Street, Baltimore, MD 21201, United States. mira.ghneim@som.umaryland.edu
Key Words Emergency general surgery; Cirrhosis; Outcomes; Mortality; Model for end-stage liver disease
Core Tip For cirrhotic patients requiring emergency general surgery, initial model for end-stage liver disease (MELD) score alone may be insufficient for perioperative risk assessment, as MELD can change postoperatively. In this single-center retrospective study of 94 patients, MELD at discharge/death was independently associated with in-hospital mortality, whereas admission and day-of-surgery MELD were not. Among 24 patients whose MELD improved after surgery, 92% survived; among 14 whose MELD worsened, 93% died. All patients with final MELD ≥ 30 died. Increases in MELD were primarily driven by bilirubin and creatinine, highlighting the need for targeted post-operative strategies to limit renal and hepatic dysfunction.
Publish Date 2026-04-21 08:57
Citation

Zhang AL, Tessema N, Clark J, Vesselinov R, O’Meara L, Efron DT, Ghneim MH. In-hospital mortality and dynamic modified end-stage liver disease score after emergency general surgery in patients with cirrhosis. World J Hepatol 2026; 18(4): 116176

URL https://www.wjgnet.com/1948-5182/full/v18/i4/116176.htm
DOI https://dx.doi.org/10.4254/wjh.v18.i4.116176
Full Article (PDF) WJH-18-116176-with-cover.pdf
Manuscript File 116176_Auto_Edited_065644.docx
Answering Reviewers 116176-answering-reviewers.pdf
Audio Core Tip 116176-audio.m4a
Biostatistics Review Certificate 116176-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 116176-conflict-of-interest-statement.pdf
Copyright License Agreement 116176-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 116176-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 116176-institutional-review-board-statement.pdf
Supplementary Material 116176-supplementary-material.pdf
Peer-review Report 116176-peer-reviews.pdf
Scientific Misconduct Check 116176-scientific-misconduct-check.png
Scientific Editor Work List 116176-scientific-editor-work-list.pdf
CrossCheck Report 116176-crosscheck-report.pdf