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Articles Published Processes
8/20/2026 6:54:19 AM | Browse: 1 | Download: 0
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Received |
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2025-11-06 06:54 |
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Peer-Review Started |
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2025-11-06 06:55 |
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First Decision by Editorial Office Director |
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2026-01-09 07:58 |
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Return for Revision |
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2026-01-09 07:58 |
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Revised |
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2026-01-16 15:39 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-28 02:32 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-28 07:24 |
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Articles in Press |
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2026-02-28 07:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-14 01:18 |
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Publish the Manuscript Online |
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2026-08-20 06:54 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Editorial |
| Article Title |
X inactive specific transcript drives mitochondrial metabolic rewiring and neural stem cell fate after spinal cord injury
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jin-Ke Sun, Zhen Shi, Xiao-Dong Tang, Bo-Kang Lv, Peng-Yu Lu, Yi-Gong Tian, Yan-Wei Fan and Peng Yan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Scientific Research Projects of Colleges and Universities in Henan Province |
26A320038 |
| Henan Province Medical Science and Technology Research Plan Project (Joint Construction) |
LHGJ20250403, LHGJ20220566, LHGJ20240365 |
| Key Research and Development Program of Henan Province |
231111311000 |
| Medical Education Research Project in Henan Province |
WJLX2023079 |
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| Corresponding Author |
Peng Yan, MD, Professor, Third Department of Orthopedics, The Fifth Affiliated Hospital of Zhengzhou University, No. 3 Kangfu Qianjie, Erqi District, Zhengzhou 450052, Henan Province, China. summun1980@sina.com |
| Key Words |
Carnitine palmitoyltransferase 1A; Insulin like growth factor 2 messenger RNA binding protein 2; Long noncoding RNA; Mitochondrial metabolism; Neural stem cells; Regenerative medicine; Spinal cord injury; X inactive specific transcript |
| Core Tip |
This study highlights the pivotal role of the long noncoding RNA X inactive specific transcript as a metabolic-epigenetic regulator in spinal cord injury. By stabilizing carnitine palmitoyltransferase 1A messenger RNA through insulin like growth factor 2 messenger RNA binding protein 2, it enhances fatty acid oxidation and mitochondrial oxidative phosphorylation, promoting neural stem cell differentiation and functional recovery. The proposed framework integrates mitochondrial metabolism, lineage regulation, and regenerative strategies, providing a conceptual bridge from molecular mechanisms to translational medicine. |
| Publish Date |
2026-08-20 06:54 |
| Citation |
Sun JK, Shi Z, Tang XD, Lv BK, Lu PY, Tian YG, Fan YW, Yan P. X inactive specific transcript drives mitochondrial metabolic rewiring and neural stem cell fate after spinal cord injury. World J Stem Cells 2026; 18(8): 116228
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i8/116228.htm |
| DOI |
https://doi.org/10.4252/wjsc.116228 |
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