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5/28/2026 8:52:23 AM | Browse: 2 | Download: 0
Publication Name World Journal of Psychiatry
Manuscript ID 116253
Country China
Received
2025-11-07 09:15
Peer-Review Started
2025-11-07 09:16
First Decision by Editorial Office Director
2025-12-25 07:40
Return for Revision
2025-12-25 07:40
Revised
2026-01-12 03:34
Publication Fee Transferred
2026-01-13 08:30
Second Decision by Editor
2026-03-04 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-03-04 08:02
Articles in Press
2026-03-04 08:02
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-05-07 10:27
Publish the Manuscript Online
2026-05-28 08:52
ISSN 2220-3206 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Psychiatry
Manuscript Type Case Report
Article Title Diagnostic challenges in restless abdomen syndrome: A case report
Manuscript Source Unsolicited Manuscript
All Author List Li-Shan Ren, Zheng-He Yu, Hong-Jing Mao and Wen-Juan Liu
ORCID
Author(s) ORCID Number
Li-Shan Ren http://orcid.org/0009-0007-7961-4601
Wen-Juan Liu http://orcid.org/0000-0002-4138-4237
Funding Agency and Grant Number
Funding Agency Grant Number
the Hangzhou Special Project for Biomedical and Health Industry No. 2024WJC034 and No. 2023WJC189
Major projects of Hangzhou Municipal Health Commission No. Z20250275
Corresponding Author Wen-Juan Liu, Associate Chief Physician, Department of Sleep Medicine, Affiliated Mental Health Center and Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, No. 305 Tianmushan Road, Hangzhou 310013, Zhejiang Province, China. juan_2001juan@163.com
Key Words Restless abdomen syndrome; Restless legs syndrome; Comorbidity of anxiety and insomnia; Dopaminergic therapy; Case report
Core Tip Restless abdomen syndrome is an under-recognized variant of restless legs syndrome characterized by abdominal discomfort worsening at rest. This report describes a patient previously misdiagnosed with anxiety-induced insomnia. A novel finding was isolated hypotransferrinemia despite normal ferritin, suggesting a specific deficit in blood-brain barrier iron transport. The patient achieved complete remission with the dopamine agonist pramipexole. This report underscores the diagnostic value of the circadian symptom pattern and suggests that transferrin levels may offer mechanistic insights into restless legs syndrome variants, alerting clinicians to avoid misdiagnosing this treatable condition as a psychiatric disorder.
Publish Date 2026-05-28 08:52
Citation

Ren LS, Yu ZH, Mao HJ, Liu WJ. Diagnostic challenges in restless abdomen syndrome: A case report. World J Psychiatry 2026; 16(6): 116253

URL https://www.wjgnet.com/2220-3206/full/v16/i6/116253.htm
DOI https://dx.doi.org/10.5498/wjp.v16.i6.116253
Full Article (PDF) WJP-16-116253-with-cover.pdf
CARE Checklist–2016 116253-CARE-Checklist-2016.pdf
Manuscript File 116253_Auto_Edited-WJJ.docx
Answering Reviewers 116253-answering-reviewers.pdf
Audio Core Tip 116253-audio.mp3
Conflict-of-Interest Disclosure Form 116253-conflict-of-interest-statement.pdf
Copyright License Agreement 116253-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s) 116253-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate 116253-non-native-speakers.pdf
Peer-review Report 116253-peer-reviews.pdf
Scientific Misconduct Check 116253-scientific-misconduct-check.png
Scientific Editor Work List 116253-scientific-editor-work-list.pdf
CrossCheck Report 116253-crosscheck-report.pdf