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Publication Name World Journal of Gastroenterology
Manuscript ID 116258
Country China
Received
2025-11-06 04:28
Peer-Review Started
2025-11-06 04:28
First Decision by Editorial Office Director
2025-12-09 09:53
Return for Revision
2025-12-09 09:53
Revised
2025-12-11 06:04
Publication Fee Transferred
Second Decision by Editor
2026-01-13 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-13 04:25
Articles in Press
2026-01-13 04:25
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-02-27 23:09
Publish the Manuscript Online
2026-03-19 07:07
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Letter to the Editor
Article Title Reconsidering early-life bile acid amidation defect in environmental enteric dysfunction
Manuscript Source Invited Manuscript
All Author List Yu-Han Yang and Yuan Li
ORCID
Author(s) ORCID Number
Yuan Li http://orcid.org/0009-0008-6350-4632
Funding Agency and Grant Number
Corresponding Author Yuan Li, MD, Professor, West China Hospital, Sichuan University, No. 17 People’s South Road, Chengdu 610041, Sichuan Province, China. l13258389785@126.com
Key Words Bile acid metabolism; Malnutrition; Environmental enteric dysfunction; Small intestinal bacterial overgrowth; Bangladesh
Core Tip This study identifies a previously unrecognized defect in bile acid conjugation among Bangladeshi infants with environmental enteric dysfunction, linking altered bile acid metabolism to poor growth and intestinal inflammation. Elevated unconjugated primary bile acids were strongly associated with anthropometry. Further, the findings highlight a possible age-related delay in the maturation of bile acid conjugation pathways in impoverished children. This study may provide the initial insights for exploring novel therapeutic targets through bile acid pathways for treating malnourished children worldwide.
Publish Date 2026-03-19 07:07
Citation

Yang YH, Li Y. Reconsidering early-life bile acid amidation defect in environmental enteric dysfunction. World J Gastroenterol 2026; 32(12): 116258

URL https://www.wjgnet.com/1007-9327/full/v32/i12/116258.htm
DOI https://dx.doi.org/10.3748/wjg.v32.i12.116258
Full Article (PDF) WJG-32-116258-with-cover.pdf
Manuscript File 116258_Auto_Edited_072521.docx
Answering Reviewers 116258-answering-reviewers.pdf
Audio Core Tip 116258-audio.mp3
Conflict-of-Interest Disclosure Form 116258-conflict-of-interest-statement.pdf
Copyright License Agreement 116258-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 116258-non-native-speakers.pdf
Peer-review Report 116258-peer-reviews.pdf
Scientific Misconduct Check 116258-scientific-misconduct-check.png
Scientific Editor Work List 116258-scientific-editor-work-list.pdf
CrossCheck Report 116258-crosscheck-report.pdf