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Articles Published Processes
8/5/2026 7:53:12 AM | Browse: 0 | Download: 0
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Received |
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2025-11-06 04:21 |
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Peer-Review Started |
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2025-11-07 00:41 |
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First Decision by Editorial Office Director |
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2025-12-18 09:22 |
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Return for Revision |
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2025-12-18 09:22 |
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Revised |
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2025-12-19 14:21 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-26 02:51 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-26 07:20 |
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Articles in Press |
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2026-01-26 07:20 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-22 08:37 |
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Publish the Manuscript Online |
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2026-08-05 07:53 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biology |
| Manuscript Type |
Correspondence |
| Article Title |
Letter to the Editor: Leptin gene hypomethylation - a missing epigenetic link in lean type 2 diabetes?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jin-Wei Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82170406, 81970238. |
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| Corresponding Author |
Jin-Wei Zhang, PhD, Professor, State Key Laboratory of Chemical Biology, Research Center of Chemical Kinomics, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, No. 345 Lingling Road, Shanghai 200032, China. jinweizhang@sioc.ac.cn |
| Key Words |
Leptin; DNA methylation; Epigenetics; Type 2 diabetes mellitus; Prediabetes; Lean-phenotype; Non-obese; Biomarkers |
| Core Tip |
This letter critically analyzes the study by Sun et al, which demonstrates that progressive hypomethylation of the leptin (LEP) gene promoter parallels glycemic deterioration in non-obese Chinese adults. The strong inverse correlation between methylation and serum LEP levels (r = -0.95, P < 0.001) highlights an adiposity-independent epigenetic mechanism that may represent a risk factor for diabetes pathogenesis. These findings position LEP promoter methylation as a promising blood-based biomarker for early detection and intervention in non-obese individuals at risk of diabetes. |
| Publish Date |
2026-08-05 07:53 |
| Citation |
Zhang JW. Letter to the Editor: Leptin gene hypomethylation - a missing epigenetic link in lean type 2 diabetes? World J Diabetes 2026; 17(8): 116265
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| URL |
https://www.wjgnet.com/1948-9358/full/v17/i8/116265.htm |
| DOI |
https://doi.org/10.4239/wjd.116265 |
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