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Articles Published Processes
6/25/2026 8:21:23 AM | Browse: 0 | Download: 0
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Received |
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2025-11-07 08:15 |
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Peer-Review Started |
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2025-11-07 08:38 |
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First Decision by Editorial Office Director |
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2025-11-28 07:51 |
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Return for Revision |
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2025-11-28 07:51 |
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Revised |
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2025-11-30 05:06 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-12 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-12 12:38 |
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Articles in Press |
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2026-01-12 12:38 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-17 07:37 |
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Publish the Manuscript Online |
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2026-06-25 08:21 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biology |
| Manuscript Type |
Correspondence |
| Article Title |
Letter to the Editor: Thymoquinone targets endoplasmic reticulum stress to rescue tendon stem cell identity - a new era for tendinopathy therapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jin-Wei Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82170406, 81970238 |
| The Royal Society United Kingdom |
IEC\NSFC\201094 |
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| Corresponding Author |
Jin-Wei Zhang, Institute of Biomedical and Clinical Sciences, Medical School, Faculty of Health and Life Sciences, University of Exeter, Hatherly Laboratories, Streatham Campus, Stocker Road, Exeter EX4 4PS, United Kingdom. j.zhang5@exeter.ac.uk |
| Key Words |
Thymoquinone; Tendon-derived stem cells; Endoplasmic reticulum stress; Signaling pathway; Tendinopathy; Chondrogenic differentiation |
| Core Tip |
This article critically analyzes the study by Tu et al, which demonstrated that tendon micro-injury activates endoplasmic reticulum (ER) stress signaling through the protein kinase RNA-like ER kinase/eukaryotic initiation factor 2/activating transcription factor 4/enhancer-binding protein homologous protein pathway, thereby promoting the chondrogenic differentiation of tendon-derived stem cells. Treatment with thymoquinone markedly alleviated ER stress and suppressed aberrant differentiation both in cultured cells and an in vivo rat model of treadmill-induced tendon injury. Collectively, these findings highlight thymoquinone as a promising therapeutic candidate for the prevention and treatment of tendinopathy by targeting ER stress-mediated cellular misdifferentiation. |
| Publish Date |
2026-06-25 08:21 |
| Citation |
Zhang JW. Letter to the Editor: Thymoquinone targets endoplasmic reticulum stress to rescue tendon stem cell identity - a new era for tendinopathy therapy. World J Stem Cells 2026; 18(6): 116276
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i6/116276.htm |
| DOI |
https://doi.org/10.4252/wjsc.116276 |
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