| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Basic Study |
| Article Title |
Erythropoietin-overexpressing mesenchymal stem cells accelerate diabetic wound healing via steroid signaling pathway modulation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bao-Dong Ma, Shu-Juan Zhang, Yi-Ming Shao, Ran-Ran Jin, Lei Sun, Peng-Ju Lv, Han Yue, Shou-Kui Hu and Xi-Wen Ma |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Project of Henan Province |
242102310112, LHGJ20230786 |
| Incubation Project of Advanced Medical Research Center |
XJYXZX2021007 |
|
| Corresponding Author |
Xi-Wen Ma, MD, Professor, Department of Geriatric, Zhengzhou Central Hospital Affiliated to Zhengzhou University, No. 16 Tongbai North Road, Zhongyuan District, Zhengzhou 450007, Henan Province, China. maxiwen@zzu.edu.cn |
| Key Words |
Diabetic wound healing; Erythropoietin; Mesenchymal stem cells; Proteomics; Single-cell RNA sequencing; Transcriptomics |
| Core Tip |
This study shows that erythropoietin-overexpressing mesenchymal stem cells (EPO-MSCs) accelerate diabetic wound repair by enhancing fibroblast migration, angiogenesis, and macrophage polarization. Integrated transcriptomic, proteomic, and single-cell analyses identify serum amyloid A3-positive reparative macrophages and C-C motif chemokine ligand-centered macrophage-neutrophil crosstalk as key immune nodes modulated by EPO-MSCs, alongside changes in steroid-related pathways. These mechanistic insights suggest that gene-engineered mesenchymal stem cells can overcome the chronic inflammatory microenvironment of diabetic wounds and provide a rationale for future dose optimization, safety evaluation, and early-phase clinical trials of EPO-MSCs therapy. |
| Publish Date |
2026-05-25 07:47 |
| Citation |
Ma BD, Zhang SJ, Shao YM, Jin RR, Sun L, Lv PJ, Yue H, Hu SK, Ma XW. Erythropoietin-overexpressing mesenchymal stem cells accelerate diabetic wound healing via steroid signaling pathway modulation. World J Stem Cells 2026; 18(5): 116280 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i5/116280.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i5.116280 |
