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Articles Published Processes
5/26/2026 5:34:20 AM | Browse: 0 | Download: 0
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Received |
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2025-11-17 12:00 |
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Peer-Review Started |
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2025-11-17 12:00 |
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First Decision by Editorial Office Director |
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2025-12-29 09:25 |
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Return for Revision |
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2025-12-29 09:25 |
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Revised |
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2026-01-13 13:13 |
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Publication Fee Transferred |
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2026-01-15 07:25 |
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Second Decision by Editor |
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2026-03-06 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-06 07:47 |
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Articles in Press |
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2026-03-06 07:47 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-29 03:04 |
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Publish the Manuscript Online |
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2026-05-26 05:34 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Salidroside mitigates experimental colitis through cyclic adenosine monophosphate pathway activation and suppression of enteric glial cell responses
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan Li, Sha-Sha Tao, Yan Wang, Qian Sun, Meng-Ying Li, Hua Zhang and Yun-Qing Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82504388 |
| National Natural Science Foundation of China |
No. 82471254 |
| National Natural Science Foundation of China |
No. 82221001 |
| Key Research and Development Program of Shaanxi Province |
No. 2022SF160 |
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| Corresponding Author |
Yun-Qing Li, PhD, Professor, College of Life Sciences, Northwest University, No. 229 Taibai North Road, Beilin District, Xi’an 710069, Shaanxi Province, China. deptanat@fmmu.edu.cn |
| Key Words |
Ulcerative colitis; Cyclic adenosine monophosphate-dependent protein kinase signaling; Enteric glial cells; Enteric nervous system; Enteric nervous network |
| Core Tip |
Salidroside (Sal) exerts protective effects in dextran sulfate sodium-induced colitis by modulating enteric glial cell (EGC) activity. Sal suppresses pathological EGC activation, reducing inflammatory mediators such as interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and nuclear factor kappa-B, while enhancing glial cell line-derived neurotrophic factor (GDNF) production. These effects restore mucosal barrier integrity, normalize intestinal permeability, and improve epithelial tight junction structure. Mechanistically, Sal activates the cyclic adenosine monophosphate (cAMP)/protein kinase A/cAMP-response element binding protein signaling pathway, linking EGC regulation to anti-inflammatory outcomes. This study highlights Sal as a promising therapeutic agent for ulcerative colitis, emphasizing the critical role of the enteric nervous system and EGCs in maintaining intestinal homeostasis. |
| Publish Date |
2026-05-26 05:34 |
| Citation |
Li Y, Tao SS, Wang Y, Sun Q, Li MY, Zhang H, Li YQ. Salidroside mitigates experimental colitis through cyclic adenosine monophosphate pathway activation and suppression of enteric glial cell responses. World J Gastroenterol 2026; 32(21): 116337 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i21/116337.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i21.116337 |
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