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Articles Published Processes
3/15/2026 6:17:27 AM | Browse: 27 | Download: 82
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Received |
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2025-11-10 03:00 |
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Peer-Review Started |
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2025-11-10 03:00 |
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First Decision by Editorial Office Director |
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2025-12-16 09:21 |
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Return for Revision |
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2025-12-16 09:21 |
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Revised |
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2025-12-23 13:56 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-11 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-11 08:07 |
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Articles in Press |
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2026-02-11 08:07 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-04 02:01 |
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Publish the Manuscript Online |
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2026-03-15 06:17 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Minireviews |
| Article Title |
Double-edged role of N6-methyladenosine reader YTH structural domain family protein 2 in neurological disorders: Molecular mechanisms and translational prospects
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yu-Meng Liu, Ming Liu, Hang Yuan and Bin Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82504755 |
| Top-level Talents Support Program of Yangzhou University |
137013152 |
| the “Lv Yang Jin Feng” Outstanding Doctor of Yangzhou |
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| Corresponding Author |
Bin Li, Assistant Professor, PhD, Institute of Comparative Medicine, Yangzhou University, No. 88 Daxue South Road, Yangzhou 225009, Jiangsu Province, China. lib111701@163.com |
| Key Words |
YTH structural domain family protein 2; N6-methyladenosine; Alzheimer’s disease; Parkinson’s disease; Glioblastoma |
| Core Tip |
This mini-review synthesizes evidence that the N6-methyladenosine (m6A) reader YTH structural domain family (YTHDF) 2 exerts context-dependent, often bidirectional effects in neurodegeneration and glioma by directing degradation of m6A-marked transcripts. YTHDF2 is regulated by upstream axes and interacts functionally with m6A writers/erasers. Because its net effect depends on cell type, brain region, disease stage and target dosage, YTHDF2 constitutes both a mechanistic biomarker and a selectively tractable therapeutic target; advancing translation will require cell/region-resolved targetome mapping, longitudinal dynamics, and testing of conditional genetics, small molecules and antisense oligonucleotides. |
| Publish Date |
2026-03-15 06:17 |
| Citation |
Liu YM, Liu M, Yuan H, Li B. Double-edged role of N6-methyladenosine reader YTH structural domain family protein 2 in neurological disorders: Molecular mechanisms and translational prospects. World J Exp Med 2026; 16(1): 116383 |
| URL |
https://www.wjgnet.com/2220-315x/full/v16/i1/116383.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v16.i1.116383 |
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