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Articles Published Processes
9/24/2026 6:23:44 AM | Browse: 0 | Download: 0
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Received |
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2025-11-12 07:08 |
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Peer-Review Started |
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2025-11-12 07:08 |
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First Decision by Editorial Office Director |
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2025-12-19 08:07 |
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Return for Revision |
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2025-12-19 08:07 |
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Revised |
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2025-12-28 09:15 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-03 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-03 09:09 |
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Articles in Press |
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2026-02-03 09:09 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-15 08:26 |
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Publish the Manuscript Online |
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2026-09-24 06:23 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Developmental Biology |
| Manuscript Type |
Editorial |
| Article Title |
Protocol defines product: Navigating function, safety and translation of induced pluripotent stem cell-derived mesenchymal stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chee-Yin Wong |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Chee-Yin Wong, PhD, /, ALPS Group Inc., The ICON, East Wing Tower, Level 18-01 & 18-02, No. 1 Jalan 1/68F, Off Jalan Tun Razak, Kuala Lumpur 50400, Malaysia. wongcy@celestialab.com |
| Key Words |
Induced pluripotent stem cell-derived mesenchymal stem cell; Induced pluripotent stem cell; Mesenchymal stem cell; Good manufacturing practices; Potency assay; Critical quality attribute; Clinical translation |
| Core Tip |
This editorial highlights the emerging principle that in induced pluripotent stem cell-derived mesenchymal stem cell (iMSC) development, protocol defines product. Drawing on recent comparative data, it underscores how different derivation routes yield functionally distinct iMSCs despite meeting minimal mesenchymal stem cell criteria. The piece advocates aligning differentiation methods with therapeutic mechanisms, embedding genomic safety early, and designing good manufacturing practices-ready, comparable manufacturing processes. By integrating biological insight with process discipline, iMSC technology can achieve reproducibility, potency, and safety, thereby turning conceptual promise into clinically reliable cell therapies. |
| Publish Date |
2026-09-24 06:23 |
| Citation |
Wong CY. Protocol defines product: Navigating function, safety and translation of induced pluripotent stem cell-derived mesenchymal stem cells. World J Stem Cells 2026; 18(9): 116437
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i9/116437.htm |
| DOI |
https://doi.org/10.4252/wjsc.116437 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
