| Category |
Cell Biology |
| Manuscript Type |
Autobiography |
| Article Title |
CYLD deletion triggers nuclear factor-kB-signaling and increases cell death resistance in murine hepatocytes
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Toni Urbanik, Bruno Christian Koehler, Laura Wolpert, Christin Elßner, Anna-Lena Scherr, Thomas Longerich, Nicole Kautz, Stefan Welte, Nadine Hövelmeyer, Dirk Jäger, Ari Waisman and Henning Schulze-Bergkamen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Dietmar Hopp Stiftung, http://www.dietmar-hopp-stiftung.de |
|
| German Research Foundation (Deutsche Forschungsgemeinschaft) |
DFG SCHU 1443/3-2 (to HSB) |
| German Research Foundation (Deutsche Forschungsgemeinschaft) |
SFB/TRR 77 |
|
| Corresponding Author |
Henning Schulze-Bergkamen, MD, National Center for Tumor Diseases, Department of Medical Oncology, University Clinic of Heidelberg, Im Neuenheimer Feld 460, 69120 Heidelberg, Baden-Wuerrtemberg, Germany. henning.schulze@med.uni-heidelberg.de |
| Key Words |
CYLD; Apoptosis; Nuclear factor-B; Tumor necrosis factor-; CD95; Liver |
| Core Tip |
Activation of death receptors, such as CD95 (Fas/APO-1) and tumor necrosis factor (TNF)-R1, is involved in the pathophysiology of acute and chronic liver diseases. Inactivation of the deubiquitinase CYLD is accompanied by increased survival of different cell types. However, the role of CYLD in death receptor-mediated apoptosis of hepatocytes has not been addressed so far. The study showed for the first time that CYLD negative hepatocytes are less sensitive to CD95 and TNF-R-mediated apoptosis, at least in part via triggering nuclear factor-?B signaling leading to induction of anti-apoptotic proteins. Inhibition of CYLD might represent a therapeutic approach to protect hepatocytes from death receptor-mediated apoptosis. |
| Publish Date |
2014-12-10 15:52 |
| Citation |
Urbanik T, Koehler BC, Wolpert L, Elßner C, Scherr AL, Longerich T, Kautz N, Welte S, Hövelmeyer N, Jäger D, Waisman A, Schulze-Bergkamen H. CYLD deletion triggers nuclear factor-B-signaling and increases cell death resistance in murine hepatocytes. World J Gastroenterol 2014; 20(45): 17049-1706 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i45/17049.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i45.17049 |
