BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
5/29/2026 7:26:45 AM | Browse: 1 | Download: 14
 |
Received |
|
2025-11-13 05:49 |
|
Peer-Review Started |
|
2025-11-13 08:13 |
|
First Decision by Editorial Office Director |
|
2025-12-30 07:35 |
|
Return for Revision |
|
2025-12-30 07:35 |
|
Revised |
|
2026-01-11 14:55 |
|
Publication Fee Transferred |
|
2026-01-12 02:05 |
|
Second Decision by Editor |
|
2026-02-28 02:30 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-02-28 07:37 |
|
Articles in Press |
|
2026-02-28 07:37 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-05-18 00:38 |
|
Publish the Manuscript Online |
|
2026-05-29 07:26 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Association between proton pump inhibitor use and the risk of inflammatory bowel disease: A systematic review and meta-analysis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Min Gao, Rui-Rui Yin, Xin Mao, Zong-Xin Shao and Yan-Yan Shi |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Natural Science Foundation of China |
J230002 |
|
| Corresponding Author |
Yan-Yan Shi, MD, Professor, Research Center of Clinical Epidemiology, Peking University Third Hospital, No. 49 Garden North Road, Haidian District, Beijing 100191, China. shiyanyan@bjmu.edu.cn |
| Key Words |
Inflammatory bowel disease; Proton pump inhibitor; Risk factor; Observational study; Protopathic bias |
| Core Tip |
Proton pump inhibitors (PPIs) are among the most commonly prescribed medications worldwide, yet their long-term safety remains under debate. This systematic review and meta-analysis demonstrate a statistically significant association between PPI use and an increased risk of incident inflammatory bowel disease. However, substantial heterogeneity and sensitivity analyses suggest that this association may be influenced by study design, age differences, and protopathic bias, thereby limiting causal inference. Clinicians should interpret this association cautiously, and future prospective studies with rigorous bias control are needed to determine whether PPI use contributes to inflammatory bowel disease pathogenesis. |
| Publish Date |
2026-05-29 07:26 |
| Citation |
Gao M, Yin RR, Mao X, Shao ZX, Shi YY. Association between proton pump inhibitor use and the risk of inflammatory bowel disease: A systematic review and meta-analysis. World J Gastroenterol 2026; 32(22): 116469 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i22/116469.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i22.116469 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
