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Articles Published Processes
2/12/2026 11:20:23 AM | Browse: 1 | Download: 1
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Received |
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2025-11-12 02:18 |
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Peer-Review Started |
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2025-11-12 02:19 |
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First Decision by Editorial Office Director |
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2025-12-09 07:28 |
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Return for Revision |
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2025-12-09 07:28 |
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Revised |
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2025-12-16 03:36 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-05 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-05 10:34 |
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Articles in Press |
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2026-01-05 10:34 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-04 00:37 |
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Publish the Manuscript Online |
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2026-02-12 11:20 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Integrating molecular and immune biomarkers for precision therapy in hepatitis B: Associated hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Pranjal Kashiv, Khushboo Saxena, Manish Ramesh Balwani and Vivek Balkrishna Kute |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Vivek Balkrishna Kute, Professor, Department of Nephrology, Institute of Kidney Diseases and Research Center, Dr HL Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Ahmedabad 380016, Gujarat, India. drvivekkute@rediffmail.com |
| Key Words |
Hepatitis B virus-associated hepatocellular carcinoma; LINC01554; CD4+ central memory T cells; Sintilimab; Lenvatinib; Multi-omic biomarkers; Immune checkpoint inhibitors; Precision hepatology |
| Core Tip |
Hepatitis B virus-associated hepatocellular carcinoma exemplifies the complexity of inflammation-driven oncogenesis. The integration of molecular and immune biomarkers enables a more precise prediction of therapeutic response. Emerging multiomic evidence identifies a triad of high LINC01554 expression, increased CD4+ central memory T cells, and solitary tumour morphology that signifies restrained oncogenic signalling, preserved immune competence, and limited clonal heterogeneity. Recognition of this molecular-immune-anatomical interplay provides a biologic framework for patient selection, response monitoring, and rational sequencing of sintilimab and lenvatinib, representing a decisive step toward scientifically grounded precision hepatology in viral hepatocellular carcinoma. |
| Publish Date |
2026-02-12 11:20 |
| Citation |
Kashiv P, Saxena K, Balwani MR, Kute VB. Integrating molecular and immune biomarkers for precision therapy in hepatitis B: Associated hepatocellular carcinoma. World J Hepatol 2026; 18(2): 116475 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i2/116475.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i2.116475 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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