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Publication Name World Journal of Diabetes
Manuscript ID 116477
Country United Kingdom
Received
2025-11-12 02:09
Peer-Review Started
2025-11-12 05:45
First Decision by Editorial Office Director
2025-12-11 08:13
Return for Revision
2025-12-11 08:13
Revised
2025-12-12 18:50
Publication Fee Transferred
Second Decision by Editor
2026-01-12 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-12 09:21
Articles in Press
2026-01-12 09:21
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-06-03 12:06
Publish the Manuscript Online
2026-06-11 11:23
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Editorial
Article Title Glucagon-like peptide-1 receptor agonists in type 2 diabetes: Evidence for disease modification and therapeutic switching
Manuscript Source Invited Manuscript
All Author List Vanishri Ganakumar, Cornelius J Fernandez and Joseph M Pappachan
ORCID
Author(s) ORCID Number
Vanishri Ganakumar http://orcid.org/0000-0003-1834-519X
Cornelius J Fernandez http://orcid.org/0000-0002-1171-5525
Joseph M Pappachan http://orcid.org/0000-0003-0886-5255
Funding Agency and Grant Number
Corresponding Author Joseph M Pappachan, FRCP, MD, MRCP, Professor, Senior Researcher, Faculty of Science, Manchester Metropolitan University, All Saints Building, Oxford Road, Manchester M15 6BH, Greater Manchester, United Kingdom. drpappachan@yahoo.co.in
Key Words Glucagon-like peptide-1 receptor agonists; Incretin polyagonists; Type 2 diabetes mellitus; Switching glucagon-like peptide-1 receptor agonist; Glycemic control
Core Tip Pharmacological manipulation of the incretin system has revolutionised the management of type 2 diabetes mellitus (T2DM) in the 21st century. The first few drug molecules in this group were the glucagon-like peptide-1 receptor agonists (GLP-1RA), which have been used for treating patients with T2DM in the past 2 decades. Newer molecules, including incretin polyagonists, with longer half-lives and dosing intervals, and better cardiometabolic outcomes, are being added recently. A study by Kassem et al published in the World Journal of Diabetes provides us with robust evidence from a large real-world study from Israel on the benefits of switching from an old GLP-1RA to a newer agent, the theme of this editorial.
Publish Date 2026-06-11 11:23
Citation

Ganakumar V, Fernandez CJ, Pappachan JM. Glucagon-like peptide-1 receptor agonists in type 2 diabetes: Evidence for disease modification and therapeutic switching. World J Diabetes 2026; 17(6): 116477

URL https://www.wjgnet.com/1948-9358/full/v17/i6/116477.htm
DOI https://doi.org/10.4239/wjd.116477
Full Article (PDF) WJD-17-116477-with-cover.pdf
Manuscript File 116477_Auto_Edited-YJP.docx
Answering Reviewers 116477-answering-reviewers.pdf
Audio Core Tip 116477-audio.m4a
Conflict-of-Interest Disclosure Form 116477-conflict-of-interest-statement.pdf
Copyright License Agreement 116477-copyright-assignment.pdf
Peer-review Report 116477-peer-reviews.pdf
Scientific Misconduct Check 116477-scientific-misconduct-check.png
Scientific Editor Work List 116477-scientific-editor-work-list.pdf
CrossCheck Report 116477-crosscheck-report.pdf