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Articles Published Processes
2/28/2026 7:48:47 AM | Browse: 12 | Download: 44
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Received |
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2025-11-13 04:47 |
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Peer-Review Started |
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2025-11-13 04:47 |
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First Decision by Editorial Office Director |
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2025-12-04 09:03 |
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Return for Revision |
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2025-12-04 09:03 |
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Revised |
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2025-12-05 00:11 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-07 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-07 06:52 |
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Articles in Press |
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2026-01-07 06:52 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-09 01:02 |
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Publish the Manuscript Online |
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2026-02-28 07:48 |
| ISSN |
2220-3141(online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Emergency Medicine |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Neurobiological rhythms in critical care: A commentary on intensive care unit music therapy efficacy and mechanism
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Takahiko Nagamine |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Takahiko Nagamine, MD, PhD, Professor, Psychiatric Internal Medicine, Sunlight Brain Research Center, 4-13-18 Jiyugaoka, Hofu 7470066, Yamaguchi, Japan. anagamine@yahoo.co.jp |
| Key Words |
Music therapy; Neuroplasticity; Intensive care unit; Critical care; Brain-derived neurotrophic factor; Anxiety |
| Core Tip |
The single 30-minute music therapy session achieved remarkable results, including reduced patient anxiety, pain, and, crucially, lower intensive care unit (ICU) mortality (7.4% vs 19.1%) and a shorter ICU length of stay (4.97 days vs 5.70 days). To justify these powerful, long-term findings, the intervention must engage fundamental neurobiological pathways. Since structural brain changes and the upregulation of factors like brain-derived neurotrophic factor require sustained effort, the study's brief, one-time protocol and unblinded design introduce a major mechanistic conundrum. Future, rigorous trials with repeated sessions and credible sham controls are essential to prove that music's neurobiological power, and not just a strong attention effect, drives recovery in critically ill patients. |
| Publish Date |
2026-02-28 07:48 |
| Citation |
Nagamine T. Neurobiological rhythms in critical care: A commentary on intensive care unit music therapy efficacy and mechanism. World J Crit Care Med 2026; 15(1): 116487 |
| URL |
https://www.wjgnet.com/2220-3141/full/v15/i1/116487.htm |
| DOI |
https://dx.doi.org/10.5492/wjccm.v15.i1.116487 |
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