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Articles Published Processes
4/8/2026 7:28:55 AM | Browse: 0 | Download: 0
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Received |
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2025-11-13 05:13 |
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Peer-Review Started |
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2025-11-13 05:13 |
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First Decision by Editorial Office Director |
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2025-12-31 07:40 |
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Return for Revision |
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2025-12-31 07:40 |
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Revised |
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2026-01-09 09:16 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-23 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-23 08:37 |
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Articles in Press |
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2026-01-23 08:37 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-27 08:41 |
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Publish the Manuscript Online |
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2026-04-08 07:28 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Digital polymerase chain reaction detection of telomerase reverse transcriptase promoter mutations in hepatitis B virus related hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shuai Shao, Yu Xiong, Mo-Wei Kong, Yang Yu and Chun-Xiang Zhang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Chun-Xiang Zhang, MD, PhD, Professor, Department of Cardiology, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou 646000, Sichuan Province, China. zhangchx999@163.com |
| Key Words |
Telomerase reverse transcriptase promoter mutation; Digital polymerase chain reaction; Hepatitis B virus; Hepatocellular carcinoma; Telomerase activation; Prognostic biomarker; Liquid biopsy |
| Core Tip |
This study provides the first systematic evidence that an optimized digital polymerase chain reaction assay can achieve ultra-sensitive detection of the guanine-cytosine-rich telomerase reverse transcriptase (TERT) promoter C228T mutation in hepatitis B virus-related hepatocellular carcinoma, with 100% sensitivity and a detection limit of 0.55 cp/μL - far surpassing traditional sequencing methods. By integrating TERT mutation status with clinical variables, we developed a prognostic nomogram that accurately predicts overall and disease-free survival, enabling early recurrence detection through ctDNA-based liquid biopsy. This work bridges molecular mechanism and clinical translation, establishing TERT mutation detection by digital polymerase chain reaction as a cornerstone technology for precision hepatocarcinology and individualized postoperative surveillance. |
| Publish Date |
2026-04-08 07:28 |
| Citation |
Shao S, Xiong Y, Kong MW, Yu Y, Zhang CX. Digital polymerase chain reaction detection of telomerase reverse transcriptase promoter mutations in hepatitis B virus related hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(4): 116504 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i4/116504.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i4.116504 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
