| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Effectiveness of magnesium isoglycyrrhizinate on perioperative hepatic function protection in patients undergoing hepatectomy
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Qin Xie, Jin-Xing Wei, Jin-Yi Zhong, Xuan Luo, Hong-Kai Zhuang, Xiao-Wu Ma, Qing-Bin Wang, Wen-Liang Tan, Bing-Kun Wang, Ya-Jin Chen, Chuan-Jiang Li and Chang-Zhen Shang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82573407 |
| Basic and Applied Basic Research Foundation of Guangdong Province |
No. 2023A1515220211 |
| Furong Plan Health High Level Talent Project of Hunan Province |
No. 20250924-1015 |
|
| Corresponding Author |
Chang-Zhen Shang, Professor, Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 33 Yingfeng Road, Haizhu District, Guangzhou 510120, Guangdong Province, China. shchzh2@mail.sysu.edu.cn |
| Key Words |
Magnesium isoglycyrrhizinate; Hepatic injury; Hepatectomy; Liver function; Real-world study |
| Core Tip |
In this real-world study of 1711 patients undergoing hepatectomy, magnesium isoglycyrrhizinate demonstrated meaningful benefits in preventing and treating postoperative hepatic injuries. Perioperative magnesium isoglycyrrhizinate significantly reduced the incidence of liver injury and accelerated postoperative liver function recovery vs postoperative use alone. The patients in the prophylaxis group had significantly lower alanine aminotransferase levels on postoperative day 1 compared to the non-prophylaxis group. Even without prophylaxis, postoperative magnesium isoglycyrrhizinate was also associated with higher rates of alanine aminotransferase improvement. Multivariable analysis confirmed its independent protective effect. These findings suggest that adding preoperative magnesium isoglycyrrhizinate prophylaxis enhances postoperative hepatic recovery and benefits a broader surgical population. |
| Publish Date |
2026-05-18 10:29 |
| Citation |
Xie ZQ, Wei JX, Zhong JY, Luo X, Zhuang HK, Ma XW, Wang QB, Tan WL, Wang BK, Chen YJ, Li CJ, Shang CZ. Effectiveness of magnesium isoglycyrrhizinate on perioperative hepatic function protection in patients undergoing hepatectomy. World J Gastroenterol 2026; 32(19): 116513 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i19/116513.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i19.116513 |
