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Articles Published Processes
10/10/2026 9:09:42 AM | Browse: 0 | Download: 0
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Received |
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2025-11-13 04:56 |
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Peer-Review Started |
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2025-11-13 09:12 |
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First Decision by Editorial Office Director |
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2025-12-17 08:00 |
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Return for Revision |
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2025-12-17 08:00 |
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Revised |
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2026-01-10 08:18 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-11 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-11 04:08 |
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Articles in Press |
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2026-02-11 04:08 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-07 00:46 |
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Publish the Manuscript Online |
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2026-10-10 09:09 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Editorial |
| Article Title |
Toward a psychoneuroimmune interpretation of anxiety and depression risk in cervical cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Huan-Fang Fan, Jia Yuan and De-Hui Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| 2023 Government-funded Project of the Outstanding Talents Training Program in Clinical Medicine |
No. ZF2023165 |
| Key Research and Development Projects of Hebei Province |
No. 18277731D |
| Natural Science Foundation of Hebei Province |
No. H2024423105 |
| Hebei Provincial Administration of Traditional Chinese Medicine, Scientific Research Project |
No. 2023045 |
| Hebei Provincial Administration of Traditional Chinese Medicine, Scientific Research Project |
No. 2024023 |
| Hebei Institute of Traditional Chinese Medicine Pharmaceutical Preparation Industry Technology Special Project |
No. YJY2024006 |
| Scientific Research Project of Health Commission of Hebei Province |
No. 20220962 |
| Scientific Research Project of Health Commission of Hebei Province |
No. 20240282 |
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| Corresponding Author |
De-Hui Li, Department of Oncology II, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), No. 389 Zhongshan East Road, Chang‘an District, Shijiazhuang 050000, Hebei Province, China. 258289951@qq.com |
| Key Words |
Psycho-neuro-immune axis; Cervical cancer; Anxiety; Depression; Clinical predictive model; Mechanism |
| Core Tip |
This commentary elucidates the innovative “psycho-neuro-immune” axis mechanism underlying a predictive model for anxiety/depression in cervical cancer. The four distinct risk factors, such as advanced cancer, comprehensive therapy, low hope level, and low income level, converge via the psycho-neuro-immune axis: Physical stressors trigger an “outside-in” immune-to-brain pathway, while psychosocial stressors drive a “top-down” neuroendocrine-to-immune pathway. These pathways interact, creating a vicious cycle that sustains peripheral and central inflammation, ultimately leading to mood symptoms. This integrative framework transforms clinical risk prediction into a targetable biological model for future interventions. |
| Publish Date |
2026-10-10 09:09 |
| Citation |
Fan HF, Yuan J, Li DH. Toward a psychoneuroimmune interpretation of anxiety and depression risk in cervical cancer. World J Psychiatry 2026; 16(10): 116515
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| URL |
https://www.wjgnet.com/2220-3206/full/v16/i10/116515.htm |
| DOI |
https://doi.org/10.5498/wjp.116515 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
