| ISSN |
1948-5190 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Reduction of serum bilirubin levels after endoscopic biliary drainage in patients with extrahepatic biliary obstruction and its significance
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Kosuru Sham Charan Naidu, Suprabhat Giri, Saroj Kanta Sahu, Dibya Lochan Praharaj, Bipadabhanjan Mallick, Preetam Nath, Swati Das, Sarat Chandra Panigrahi, Manoj Kumar Sahu, Anil Chandra Anand, Yogesh K Chawla and Subrat Kumar Acharya |
| ORCID |
|
| Funding Agency and Grant Number |
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| Corresponding Author |
Bipadabhanjan Mallick, Professor, Department of Gastroenterology and Hepatology, Kalinga Institute of Medical Sciences, Kushabhadra Campus, 5 KIIT Road, Patia, Bhubaneswar 751024, Odisha, India. bipada.mallick@kims.ac.in |
| Key Words |
Endoscopic retrograde cholangiopancreatography; Extrahepatic biliary obstruction; Endoscopic biliary drainage; Malignant biliary obstruction; Choledocholithiasis |
| Core Tip |
Early bilirubin kinetics provide a simple, reliable, and clinically actionable tool after endoscopic biliary drainage for extrahepatic biliary obstruction. A ≥ 50% fall in bilirubin by day 7 indicates adequate drainage and predicts lower need for reintervention, whereas failure should prompt early reassessment for stent dysfunction or incomplete drainage. Achieving a bilirubin < 3 mg/dL by day 15 is a strong indicator of recovery, particularly in malignant obstruction; failure to do so predicts higher short-term mortality. Baseline bilirubin, alkaline phosphatase levels, etiology, and presence of acute kidney injury should guide the intensity of monitoring. Routine incorporation of bilirubin kinetics can improve post-endoscopic retrograde cholangiopancreatography decision-making and outcomes. |
| Publish Date |
2026-02-04 07:43 |
| Citation |
Naidu KSC, Giri S, Sahu SK, Praharaj DL, Mallick B, Nath P, Das S, Panigrahi SC, Sahu MK, Anand AC, Chawla YK, Acharya SK. Reduction of serum bilirubin levels after endoscopic biliary drainage in patients with extrahepatic biliary obstruction and its significance. World J Gastrointest Endosc 2026; 18(2): 116518 |
| URL |
https://www.wjgnet.com/1948-5190/full/v18/i2/116518.htm |
| DOI |
https://dx.doi.org/10.4253/wjge.v18.i2.116518 |
