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Articles Published Processes
6/25/2026 8:21:20 AM | Browse: 0 | Download: 0
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Received |
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2025-11-28 09:55 |
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Peer-Review Started |
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2025-11-28 09:55 |
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First Decision by Editorial Office Director |
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2025-12-18 09:10 |
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Return for Revision |
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2025-12-18 09:10 |
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Revised |
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2025-12-31 13:41 |
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Publication Fee Transferred |
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2026-01-09 03:43 |
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Second Decision by Editor |
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2026-03-25 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-25 09:41 |
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Articles in Press |
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2026-03-25 09:41 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-22 03:02 |
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Publish the Manuscript Online |
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2026-06-25 08:21 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Therapeutic effects of human amniotic epithelial cell-derived and umbilical cord blood mesenchymal stem cell-derived exosomes on preeclamptic rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lu-Yao Han, Wen-Zhu Zhang, Yu Zhang, Wan Zhong, Jing-Li Sun and Jian Shen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shenyang Science and Technology Plan in 2022 |
22-321-32-16 |
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| Corresponding Author |
Jian Shen, Department of Obstetrics and Gynecology, General Hospital of Northern Theater Command (Heping Campus), No. 5 Guangrong Street, Heping District, Shenyang 110000, Liaoning Province, China. shenjian99@sina.com |
| Key Words |
Human amniotic epithelial cells; Human umbilical cord blood mesenchymal stem cells; Preeclampsia; Exosomes; Vascular endothelial growth factor; Placental growth factor |
| Core Tip |
Preeclampsia (PE) is a serious obstetric syndrome, and effective therapeutic options are required urgently. This study demonstrates that exosomes derived from human amniotic epithelial cells and umbilical cord mesenchymal stem cells can function as innovative cell-free agents. Treatment with these exosomes effectively ameliorated key pathological features, including hypertension, proteinuria, and placental damage, in a rat model of PE. The underlying mechanisms involve multi-target modulation of angiogenic and inflammatory pathways. These findings highlight the clinical translation potential of exosomes derived from human amniotic epithelial cells and umbilical cord mesenchymal stem cells as novel therapeutic strategies for PE. |
| Publish Date |
2026-06-25 08:21 |
| Citation |
Han LY, Zhang WZ, Zhang Y, Zhong W, Sun JL, Shen J. Therapeutic effects of human amniotic epithelial cell-derived and umbilical cord blood mesenchymal stem cell-derived exosomes on preeclamptic rats. World J Stem Cells 2026; 18(6): 116526
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i6/116526.htm |
| DOI |
https://doi.org/10.4252/wjsc.116526 |
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