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Articles Published Processes
4/14/2026 5:58:21 AM | Browse: 0 | Download: 0
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Received |
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2025-11-14 11:40 |
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Peer-Review Started |
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2025-11-17 00:36 |
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First Decision by Editorial Office Director |
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2025-11-26 08:19 |
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Return for Revision |
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2025-11-26 08:19 |
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Revised |
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2025-12-04 16:34 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-08 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-08 11:12 |
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Articles in Press |
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2026-01-08 11:12 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-02 06:42 |
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Publish the Manuscript Online |
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2026-04-14 05:58 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Correspondence |
| Article Title |
Letter to the Editor: Ca2+/calmodulin-dependent protein kinase II in heart failure and the role of sodium-glucose-cotransporter 2 inhibitors
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Fei Zhang, Wu-Xiao Yang and Xue-Wen Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 8217022047 |
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| Corresponding Author |
Xue-Wen Li, Chief Physician, PhD, Professor, Department of Cardiology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, No. 99 Longcheng Street, Taiyuan 030032, Shanxi Province, China. xuewenli1010@126.com |
| Key Words |
Sodium-glucose cotransporter 2 inhibitor; Heart failure; Ca2+/calmodulin-dependent protein kinase II; Oxidative stress; Calcium homeostasis |
| Core Tip |
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have revolutionized the treatment of heart failure, but their direct molecular effects in cardiomyocytes, which express little sodium-glucose cotransporter-2, have not been fully described. This letter summarizes current evidence and presents a conceptual framework in which Ca2+/calmodulin-dependent protein kinase II is a central target. We hypothesize that many of the cardioprotective effects of SGLT2i are mediated by the dampening of Ca2+/calmodulin-dependent protein kinase II activity through synergistic modulation of ionic balance, relief of oxidative stress and inflammatory signaling suppression. Together, these processes may provide a unified explanation for the observed improvements in electrical stability, ventricular performance, and cardiac remodeling associated with SGLT2i treatment. |
| Publish Date |
2026-04-14 05:58 |
| Citation |
Zhang YF, Yang WX, Li XW. Letter to the Editor: Ca2+/calmodulin-dependent protein kinase II in heart failure and the role of sodium-glucose-cotransporter 2 inhibitors. World J Cardiol 2026; 18(4): 116558 |
| URL |
https://www.wjgnet.com/1949-8462/full/v18/i4/116558.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v18.i4.116558 |
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