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Articles Published Processes
3/12/2026 12:25:36 PM | Browse: 6 | Download: 25
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Received |
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2025-11-14 07:59 |
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Peer-Review Started |
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2025-11-14 07:59 |
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First Decision by Editorial Office Director |
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2025-11-19 09:38 |
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Return for Revision |
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2025-11-19 09:38 |
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Revised |
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2025-11-20 00:57 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-24 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-24 06:57 |
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Articles in Press |
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2025-12-24 06:57 |
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Edit the Manuscript by Language Editor |
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2026-01-02 22:29 |
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Typeset the Manuscript |
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2026-02-11 09:16 |
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Publish the Manuscript Online |
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2026-03-12 12:25 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Observational Study |
| Article Title |
Dual-parameter liquid biopsy using plasma miR-21-5p and T-cell LAIR-1 MFI for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Dalia E Sherief, Hadeer Hamdy Shehata, Nahla Nosair, Amira AA Othman, Emad Sadaka and Rasha Elgamal |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Amira AA Othman, Lecturer, MD, PhD, Principal Investigator, Department of Internal Medicine, Suez University, Cairo-Suez Road, Suez 43511, Egypt. amira.othman@med.suezuni.edu.eg |
| Key Words |
Hepatocellular carcinoma; microRNAs; hsa-miR-21-5p; hsa-miR-155-5p; Leukocyte-associated immunoglobulin-like receptor-1; Biomarkers; Receiver operating characteristic curve; Egypt |
| Core Tip |
Early, accurate, and non-invasive diagnosis of hepatocellular carcinoma (HCC) remains a major clinical challenge, particularly in Egypt, where hepatitis C virus-related cirrhosis is prevalent. This study introduces a novel dual-parameter liquid biopsy combining plasma miR-21-5p (a tumor-derived oncomiR) and T-cell leukocyte-associated immunoglobulin-like receptor-1 MFI (an immune-checkpoint marker). In a prospective Egyptian cohort, this approach achieved exceptional diagnostic accuracy (area under the curve > 0.99) and maintained high sensitivity in early-stage and α-fetoprotein-negative HCC. The findings propose an integrated molecular-immune diagnostic pathway that could substantially improve HCC surveillance and early detection in high-risk populations. |
| Publish Date |
2026-03-12 12:25 |
| Citation |
Sherief DE, Shehata HH, Nosair N, Othman AA, Sadaka E, Elgamal R. Dual-parameter liquid biopsy using plasma miR-21-5p and T-cell LAIR-1 MFI for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort. World J Gastrointest Oncol 2026; 18(3): 116567 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i3/116567.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i3.116567 |
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