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8/7/2026 9:40:27 AM | Browse: 1 | Download: 0
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 116571
Country Canada
Received
2025-11-14 10:03
Peer-Review Started
2025-11-17 00:37
First Decision by Editorial Office Director
2025-12-02 07:36
Return for Revision
2025-12-02 07:36
Revised
2025-12-03 00:23
Publication Fee Transferred
Second Decision by Editor
2026-01-05 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-06 00:47
Articles in Press
2026-01-06 00:47
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-07-08 07:09
Publish the Manuscript Online
2026-08-07 09:40
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Correspondence
Article Title Letter to the Editor: Surgical safety of RAPIDO-style total neoadjuvant therapy: Reassuring early outcomes with important nuances.
Manuscript Source Unsolicited Manuscript
All Author List Renata D’Alpino Peixoto
ORCID
Author(s) ORCID Number
Renata D’Alpino Peixoto http://orcid.org/0000-0003-0053-7951
Funding Agency and Grant Number
Corresponding Author Renata D’Alpino Peixoto, FAHA, MD, PhD, Department of Medical Oncology, British Columbia Cancer, 600 West 10th Avenue, Vancouver V5Z4E6, British Columbia, Canada. renata.peixoto@bccancer.bc.ca
Key Words Total neoadjuvant therapy; Rectal cancer; RAPIDO protocol; Surgical outcomes; Chemoradiotherapy
Core Tip This letter highlights real-world data showing that Rectal Cancer and Preoperative Induction Therapy Followed by Dedicated Operation (RAPIDO)-style total neoadjuvant therapy does not appear to increase surgical difficulty or early postoperative morbidity compared with standard long-course chemoradiotherapy. Despite prolonged intervals before surgery, key oncologic and technical metrics - such as R0 resection, total mesorectal excision completeness, and complication rates - were maintained, while stoma-related outcomes may even improve. These findings offer reassurance as total neoadjuvant therapy becomes increasingly integrated into management of locally advanced rectal cancer and underscore the need for future prospective studies incorporating objective measures of operative complexity.
Publish Date 2026-08-07 09:40
Citation

Peixoto RD. Letter to the Editor: Surgical safety of RAPIDO-style total neoadjuvant therapy: Reassuring early outcomes with important nuances.. World J Gastrointest Oncol 2026; 18(8): 116571

URL https://www.wjgnet.com/1948-5204/full/v18/i8/116571.htm
DOI https://doi.org/10.4251/wjgo.116571
Full Article (PDF) WJGO-18-116571-with-cover.pdf
Manuscript File 116571_Auto_Edited_032651.docx
Answering Reviewers 116571-answering-reviewers.pdf
Audio Core Tip 116571-audio.m4a
Conflict-of-Interest Disclosure Form 116571-conflict-of-interest-statement.pdf
Copyright License Agreement 116571-copyright-assignment.pdf
Peer-review Report 116571-peer-reviews.pdf
Scientific Misconduct Check 116571-scientific-misconduct-check.png
Scientific Editor Work List 116571-scientific-editor-work-list.pdf
CrossCheck Report 116571-crosscheck-report.pdf