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Articles Published Processes
8/24/2026 6:01:17 AM | Browse: 0 | Download: 0
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Received |
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2026-01-30 09:41 |
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Peer-Review Started |
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2026-01-30 09:42 |
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First Decision by Editorial Office Director |
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2026-02-26 06:18 |
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Return for Revision |
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2026-02-26 06:18 |
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Revised |
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2026-03-12 16:23 |
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Publication Fee Transferred |
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2026-03-31 06:14 |
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Second Decision by Editor |
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2026-05-08 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-08 10:16 |
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Articles in Press |
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2026-05-08 10:16 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-11 02:34 |
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Publish the Manuscript Online |
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2026-08-24 06:01 |
| ISSN |
2220-3206 (online) |
| Open Access |
Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Efficacy and influencing factors of 3-N-Butylphthalide-trazodone combination in managing post-ischemic stroke depression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Hua Zhu, Yong-Sen Lin and Zhu-Quan Hong |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zhu-Quan Hong, Associate Chief Physician, Department of Neurology, Quanzhou First Hospital, No. 1028 Anji South Road, Fengze District, Quanzhou 362000, Fujian Province, China. 971696252@qq.com |
| Key Words |
3-N-Butylphthalide; Trazodone; Post-ischemic stroke depression; Therapeutic effectiveness; Influencing factors |
| Core Tip |
For the optimization of treatment for post-ischemic stroke depression, this study verified the efficacy of the 3-N-Butylphthalide (NBP)-Trazodone (TRZ) combination and explored efficacy-associated determinants. Without increasing the total incidence of adverse reactions, the NBP-TRZ combination was significantly superior to TRZ monotherapy in therapeutic efficacy, while also significantly improving patients’ neurological function and daily living ability, alleviating depression, and regulating serum neurotransmitters. Comorbid hyperlipidemia, low 5-hydroxytryptamine, reduced dopamine, and TRZ monotherapy were associated with treatment ineffectiveness in such patients. |
| Publish Date |
2026-08-24 06:01 |
| Citation |
Zhu ZH, Lin YS, Hong ZQ. Efficacy and influencing factors of 3-N-Butylphthalide-trazodone combination in managing post-ischemic stroke depression. World J Psychiatry 2026; 16(9): 116579
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| URL |
https://www.wjgnet.com/2220-3206/full/v16/i9/116579.htm |
| DOI |
https://doi.org/10.5498/wjp.116579 |
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