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Articles Published Processes
5/25/2026 7:47:54 AM | Browse: 0 | Download: 0
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Received |
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2025-11-18 05:18 |
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Peer-Review Started |
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2025-11-18 05:18 |
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First Decision by Editorial Office Director |
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2025-12-31 07:56 |
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Return for Revision |
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2025-12-31 07:56 |
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Revised |
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2026-01-12 13:15 |
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Publication Fee Transferred |
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2026-01-15 08:37 |
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Second Decision by Editor |
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2026-02-14 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-24 08:52 |
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Articles in Press |
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2026-02-24 08:52 |
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Edit the Manuscript by Language Editor |
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2026-03-10 00:38 |
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Typeset the Manuscript |
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2026-04-28 01:47 |
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Publish the Manuscript Online |
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2026-05-25 07:47 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Hypoxia-preconditioned mesenchymal stem cell-derived exosomes attenuate myocardial ischemia-reperfusion injury by miR-29b-3p via PINK1/Parkin-mediated mitophagy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen Wen, Chen-Xi Liu, Yong Wang, Xiao-Jiong Lu, Chao Yang, Shuang-Jing Chen, Zhi-Tao Jin, Ming-Yue Qu, Jing-Yu Deng and Zheng Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Natural Science Foundation |
7222229 |
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| Corresponding Author |
Zheng Zhang, Associate Chief Physician, MD, Department of Cardiology, The PLA Rocket Force Characteristic Medical Center, No. 16 Xinjiekouwai Dajie, Xicheng District, Beijing 100088, China. faithword@163.com |
| Key Words |
Ischemia-reperfusion injury; Hypoxia preconditionin; Bone marrow mesenchymal stem cells; Exosomes; Mitophagy |
| Core Tip |
This study identifies hypoxia-preconditioned mesenchymal stem cell-derived exosomes as a potent therapeutic strategy for myocardial ischemia/reperfusion injury. High-throughput sequencing reveals miR-29b-3p as a key protective cargo that restores mitochondrial homeostasis by activating PINK1/Parkin-dependent mitophagy. miR-29b-3p significantly reduces oxidative stress, preserves mitochondrial integrity, and improves cardiac function in vivo, highlighting a promising exosome-based and mitochondria-targeted approach for future cardioprotection. |
| Publish Date |
2026-05-25 07:47 |
| Citation |
Wen W, Liu CX, Wang Y, Lu XJ, Yang C, Chen SJ, Jin ZT, Qu MY, Deng JY, Zhang Z. Hypoxia-preconditioned mesenchymal stem cell-derived exosomes attenuate myocardial ischemia-reperfusion injury by miR-29b-3p via PINK1/Parkin-mediated mitophagy. World J Stem Cells 2026; 18(5): 116611 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i5/116611.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i5.116611 |
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