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Articles Published Processes
7/14/2026 7:34:00 AM | Browse: 1 | Download: 0
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Received |
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2025-11-17 02:49 |
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Peer-Review Started |
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2025-11-17 02:49 |
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First Decision by Editorial Office Director |
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2025-12-31 09:43 |
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Return for Revision |
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2025-12-31 09:43 |
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Revised |
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2026-01-07 04:49 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-04 02:52 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-04 08:44 |
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Articles in Press |
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2026-02-04 08:44 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-26 04:01 |
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Publish the Manuscript Online |
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2026-07-14 07:34 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Correspondence |
| Article Title |
Not one disease: Ethnic-specific mutational pathways redefine precision oncology in esophageal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rui-Jie Ming and Hua-Wen Liu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hua-Wen Liu, MD, Professor, Department of Oncology, Chongqing University Three Gorges Hospital, No. 165 Xincheng Road, Chongqing 404010, China. liuhuawen@cqu.edu.cn |
| Key Words |
Esophageal squamous cell carcinoma; Ethnic genomics; Mutational signatures; Precision oncology; Tumor mutational burden; Health equity |
| Core Tip |
This letter highlights that esophageal squamous cell carcinoma is not a single entity but comprises ethnically distinct molecular subtypes. While Han patients exhibit the apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide-related signatures, Kazakh patients show defective mismatch repair. We emphasize a critical paradox: Despite worse historical survival, Kazakh tumors display high tumor mutational burden, suggesting potential sensitivity to immunotherapy. These findings urge the integration of ethnic genomics into clinical trial design to transform therapeutic strategies for underrepresented populations. |
| Publish Date |
2026-07-14 07:34 |
| Citation |
Ming RJ, Liu HW. Not one disease: Ethnic-specific mutational pathways redefine precision oncology in esophageal cancer. World J Gastroenterol 2026; 32(27): 116615
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i27/116615.htm |
| DOI |
https://doi.org/10.3748/wjg.116615 |
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