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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 116624
Country China
Received
2025-11-17 03:17
Peer-Review Started
2025-11-17 03:18
First Decision by Editorial Office Director
2025-12-02 07:37
Return for Revision
2025-12-02 07:37
Revised
2025-12-14 13:04
Publication Fee Transferred
Second Decision by Editor
2026-01-22 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-22 07:35
Articles in Press
2026-01-22 07:35
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-05-07 10:52
Publish the Manuscript Online
2026-06-09 09:23
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Correspondence
Article Title Bile acids in cholangiocarcinoma: Dual regulation via the hippo-yes-associated protein pathway and model limitations
Manuscript Source Invited Manuscript
All Author List Kang-Li Wu, Dong Guo, Lan Yang, Yi-Qi Li, Yi-Xin Wu, Ce-Fan Zhou and Jing-Feng Tang
ORCID
Author(s) ORCID Number
Ce-Fan Zhou http://orcid.org/0000-0003-0680-3843
Jing-Feng Tang http://orcid.org/0000-0002-5524-4518
Funding Agency and Grant Number
Funding Agency Grant Number
National Key Research and Development Program of China 2023YFC2507904
Innovation Group Project of Hubei Province 2023AFA026
Key Cultivation Project of Hubei Province for Science and Technology 2024DJA037
Corresponding Author Ce-Fan Zhou, Professor, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, No. 28 Nanli Road, Wuhan 430068, Hubei Province, China. cefan@hbut.edu.cn
Key Words Bile duct carcinoma; Hippo-yes-associated protein signaling pathway; Bile acids; Molecular targeted therapy; Cholangiocarcinoma
Core Tip Bile acids play a crucial regulatory role in the development and progression of cholangiocarcinoma through the hippo-yes-associated protein signaling pathway. In this study, we aim to evaluate the current significance and limitations of bile acids in cholangiocarcinoma via the hippo-yes-associated protein signaling pathway. Based on this assessment, we propose that future research should incorporate more diverse model systems to validate existing findings and further explore the interactions between this pathway and other signaling networks, thereby constructing a more comprehensive molecular mechanism landscape. This letter is intended to provide a theoretical reference for subsequent mechanistic investigations and clinical translational research, while also outlining potential future research directions in this field.
Publish Date 2026-06-09 09:23
Citation

Wu KL, Guo D, Yang L, Li YQ, Wu YX, Zhou CF, Tang JF. Bile acids in cholangiocarcinoma: Dual regulation via the hippo-yes-associated protein pathway and model limitations. World J Gastrointest Oncol 2026; 18(6): 116624

URL https://www.wjgnet.com/1948-5204/full/v18/i6/116624.htm
DOI https://doi.org/10.4251/wjgo.v18.i6.116624
Full Article (PDF) WJGO-18-116624-with-cover.pdf
Manuscript File 116624_Auto_Edited_074927.docx
Answering Reviewers 116624-answering-reviewers.pdf
Audio Core Tip 116624-audio.m4a
Conflict-of-Interest Disclosure Form 116624-conflict-of-interest-statement.pdf
Copyright License Agreement 116624-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 116624-non-native-speakers.pdf
Peer-review Report 116624-peer-reviews.pdf
Scientific Misconduct Check 116624-scientific-misconduct-check.png
Scientific Editor Work List 116624-scientific-editor-work-list.pdf
CrossCheck Report 116624-crosscheck-report.pdf