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4/21/2026 8:57:44 AM | Browse: 4 | Download: 12
Publication Name World Journal of Hepatology
Manuscript ID 116657
Country Italy
Received
2025-11-19 07:42
Peer-Review Started
2025-11-19 07:42
First Decision by Editorial Office Director
2025-12-24 10:13
Return for Revision
2025-12-24 10:13
Revised
2026-01-07 18:29
Publication Fee Transferred
Second Decision by Editor
2026-02-03 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-03 05:50
Articles in Press
2026-02-03 05:50
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-04-10 08:17
Publish the Manuscript Online
2026-04-21 08:57
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pediatrics
Manuscript Type Systematic Reviews
Article Title Treatment of chronic hepatitis B infection in infants and young children: A systematic review
Manuscript Source Invited Manuscript
All Author List Simona Carrera, Chiara Rubino, Elisa Bartolini and Giuseppe Indolfi
ORCID
Author(s) ORCID Number
Simona Carrera http://orcid.org/0000-0003-0123-5808
Chiara Rubino http://orcid.org/0000-0001-7480-3613
Giuseppe Indolfi http://orcid.org/0000-0003-3830-9823
Funding Agency and Grant Number
Corresponding Author Simona Carrera, MD, Pediatric and Liver Unit, Meyer Children's Hospital IRCCS, Viale Gaetano Pieraccini 24, Florence 50139, Tuscany, Italy. simona.carrera@meyer.it
Key Words Chronic hepatitis B virus infection; Children; Functional cure; Hepatitis B surface antigen loss; Antiviral treatment
Core Tip Chronic hepatitis B is a major global health issue, largely driven by mother-to-child transmission. Spontaneous hepatitis B surface antigen seroclearance occurs at about 1% per year. Emerging evidence suggests that starting antiviral therapy at a young age might lead to higher functional cure rates. This review examines evidence and implications of early treatment.
Publish Date 2026-04-21 08:57
Citation

Carrera S, Rubino C, Bartolini E, Indolfi G. Treatment of chronic hepatitis B infection in infants and young children: A systematic review. World J Hepatol 2026; 18(4): 116657

URL https://www.wjgnet.com/1948-5182/full/v18/i4/116657.htm
DOI https://dx.doi.org/10.4254/wjh.v18.i4.116657
Full Article (PDF) WJH-18-116657-with-cover.pdf
PRISMA 2009 Checklist 116657-PRISMA-2009-Checklist.pdf
Manuscript File 116657_Auto_Edited_065352.docx
Answering Reviewers 116657-answering-reviewers.pdf
Audio Core Tip 116657-audio.m4a
Biostatistics Review Certificate 116657-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 116657-conflict-of-interest-statement.pdf
Copyright License Agreement 116657-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 116657-non-native-speakers.pdf
Peer-review Report 116657-peer-reviews.pdf
Scientific Misconduct Check 116657-scientific-misconduct-check.png
Scientific Editor Work List 116657-scientific-editor-work-list.pdf
CrossCheck Report 116657-crosscheck-report.pdf