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Articles Published Processes
1/16/2026 3:25:53 AM | Browse: 0 | Download: 0
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Received |
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2025-11-18 07:04 |
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Peer-Review Started |
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2025-11-18 09:05 |
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First Decision by Editorial Office Director |
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2025-12-04 08:57 |
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Return for Revision |
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2025-12-04 08:57 |
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Revised |
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2025-12-13 15:47 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-05 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-05 03:20 |
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Articles in Press |
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2026-01-05 03:20 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-09 00:33 |
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Publish the Manuscript Online |
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2026-01-16 03:25 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Differentiating fenbendazole-induced liver injury from immunotherapy hepatitis - the importance of structured causality assessment: A case report
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Arunkumar Krishnan, Kaleb Lucas, Laura Maas and Tinsay A Woreta |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Tinsay A Woreta, MD, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21205, United States. tworeta1@jhmi.edu |
| Key Words |
Drug-induced liver injury; Fenbendazole; Hepatotoxicity; Immune checkpoint inhibitor; Roussel Uclaf Causality Assessment Method; Immunotherapy; Case report |
| Core Tip |
A middle-aged woman with metastatic colon cancer on immune checkpoint immunotherapy presented with acute hepatocellular injury. This case highlights severe fenbendazole-induced hepatocellular injury in an oncology patient receiving immune checkpoint inhibitors, where timing and causality assessment were vital for accurately attributing the liver injury. Social media-driven self-medication is becoming increasingly common among cancer patients, with fenbendazole doses often far exceeding veterinary recommendations. Prompt recognition and removal of the offending agent can allow safe continuation of immunotherapy and prevent unnecessary immunosuppression. A thorough approach to medication history-taking, including non-prescription and alternative drugs, is essential when evaluating unexplained acute liver injury. |
| Publish Date |
2026-01-16 03:25 |
| Citation |
Krishnan A, Lucas K, Maas L, Woreta TA. Differentiating fenbendazole-induced liver injury from immunotherapy hepatitis - the importance of structured causality assessment: A case report. World J Clin Cases 2026; 14(2): 116700 |
| URL |
https://www.wjgnet.com/2307-8960/full/v14/i2/116700.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v14.i2.116700 |
© 2004-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
