| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Dentistry, Oral Surgery & Medicine |
| Manuscript Type |
Review |
| Article Title |
Biological approaches and biomaterial-based solutions for bone reconstruction: A comprehensive review
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Bárbara de Oliveira Horvath Pereira, Bianca de Oliveira Horvath-Pereira, Carlos Henrique Bertoni Reis, Evelyn Lorene Rodrigues da Silva, Leandro Norberto da Silva-Júnior, Rogério Leone Buchaim and Daniela Vieira Buchaim |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| CAPES |
|
| CNPq |
302545/2025-5 |
|
| Corresponding Author |
Daniela Vieira Buchaim, PhD, Department of Anatomy, Medical School, University Center of Adamantina, Av. Francisco Bellusci, 1000 - Distrito Industrial Otavio Gacazzi, Adamantina 17800-000, Sao Paulo, Brazil. danibuchaim@alumni.usp.br |
| Key Words |
Bone regeneration; Biomaterials; Orthopedics; Dentistry; Regenerative Medicine; Low-level laser therapy; Photobiomodulation |
| Core Tip |
Regenerative medicine combines biology, engineering, and technology to achieve predictable bone regeneration. While autogenous grafts remain the gold standard for their osteogenic properties, they pose limitations such as donor site morbidity and volume constraints. Alternatives like allogeneic, xenogeneic, and synthetic materials improve biocompatibility and tissue integration. Advanced biomaterials, including bioactive scaffolds, enhance extracellular matrix mimicry, supporting cell adhesion, vascularization, and mineralized tissue formation. Emerging strategies-tissue engineering, cell therapy, and photobiomodulation show promise for osteo-genesis and repair. Integrating biological approaches with synthetic solutions offers a path toward individualized, effective, and evidence-based regenerative treatments in orthopedics. |
| Publish Date |
2026-04-10 07:08 |
| Citation |
Horvath Pereira BO, Horvath-Pereira BO, Reis CHB, da Silva ELR, da Silva-Júnior LN, Buchaim RL, Buchaim DV. Biological approaches and biomaterial-based solutions for bone reconstruction: A comprehensive review. World J Orthop 2026; 17(4): 116707 |
| URL |
https://www.wjgnet.com/2218-5836/full/v17/i4/116707.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v17.i4.116707 |
