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4/21/2026 8:57:42 AM | Browse: 6 | Download: 9
Publication Name World Journal of Hepatology
Manuscript ID 116710
Country United States
Received
2025-11-18 07:48
Peer-Review Started
2025-11-18 07:48
First Decision by Editorial Office Director
2025-11-30 01:29
Return for Revision
2025-11-30 01:29
Revised
2025-12-14 21:55
Publication Fee Transferred
Second Decision by Editor
2026-01-27 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-27 05:28
Articles in Press
2026-01-27 05:28
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-04-10 06:27
Publish the Manuscript Online
2026-04-21 08:57
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Report
Article Title Acute liver failure linked to OxyShred pre-workout supplement: A case report and review of literature
Manuscript Source Unsolicited Manuscript
All Author List Sarah Householder, Noah Brazer and Ysabel C Ilagan-Ying
ORCID
Author(s) ORCID Number
Sarah Householder http://orcid.org/0000-0002-6775-2982
Funding Agency and Grant Number
Corresponding Author Sarah Householder, Department of Internal Medicine, Yale-New Haven Hospital, 20 York Steet, New Haven, CT 06511, United States. sarah.householder@yale.edu
Key Words Dietary supplements; Drug-induced liver injury; Herbal supplements; Garcinia cambogia; Weight loss agents; Liver transplantation; Acute liver failure; Case report
Core Tip Pre-workout supplement (PWS) use has grown rapidly with the expanding fitness market, yet many products contain poorly regulated herbal ingredients linked to liver injury. Multi-ingredient supplements cause most herb-related hepatotoxicity, and consumers often assume they are regulated despite minimal oversight. OxyShred thermogenic fat burner (OxyShred), a popular PWS, includes several agents associated with liver damage. A healthy 31-year-old woman developed acute liver failure requiring transplantation after eight weeks of consistent OxyShred use. This case highlights the risks of unregulated supplements, the need for physician inquiry about PWS use, and the importance of stronger federal requirements for safety evidence and ingredient transparency.
Publish Date 2026-04-21 08:57
Citation

Householder S, Brazer N, Ilagan-Ying YC. Acute liver failure linked to OxyShred pre-workout supplement: A case report and review of literature. World J Hepatol 2026; 18(4): 116710

URL https://www.wjgnet.com/1948-5182/full/v18/i4/116710.htm
DOI https://dx.doi.org/10.4254/wjh.v18.i4.116710
Full Article (PDF) WJH-18-116710-with-cover.pdf
CARE Checklist–2016 116710-CARE-Checklist-2016.pdf
Manuscript File 116710_Auto_Edited_065311.docx
Answering Reviewers 116710-answering-reviewers.docx
Audio Core Tip 116710-audio.m4a
Conflict-of-Interest Disclosure Form 116710-conflict-of-interest-statement.pdf
Copyright License Agreement 116710-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s) 116710-informed-consent-statement.pdf
Peer-review Report 116710-peer-reviews.pdf
Scientific Misconduct Check 116710-scientific-misconduct-check.png
Scientific Editor Work List 116710-scientific-editor-work-list.pdf
CrossCheck Report 116710-crosscheck-report.pdf