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Articles Published Processes
6/26/2026 9:50:20 AM | Browse: 0 | Download: 0
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Received |
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2025-11-19 12:33 |
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Peer-Review Started |
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2025-11-19 12:33 |
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First Decision by Editorial Office Director |
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2025-12-05 08:59 |
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Return for Revision |
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2025-12-05 08:59 |
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Revised |
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2026-02-25 14:47 |
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Publication Fee Transferred |
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2026-03-01 14:59 |
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Second Decision by Editor |
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2026-04-28 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-28 07:29 |
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Articles in Press |
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2026-04-28 07:29 |
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Edit the Manuscript by Language Editor |
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2026-05-03 00:58 |
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Typeset the Manuscript |
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2026-05-29 06:47 |
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Publish the Manuscript Online |
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2026-06-26 09:50 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Plasma exosomal miR-137 activates natural killer cells in primary biliary cholangitis by targeting NFATC1
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Fei Yang, Qi-Xuan Liu, Wen-Hao Su, Bo Zang, Bing-Qian Liu, Chen-Yang Zhao, Yi-Bing Han, Ling-Wei Liu, Patrick S C Leung and Bin Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81671600 and No. 81241094 |
| the Natural Science Foundation of Shandong Province |
No. ZR2023MH066 |
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| Corresponding Author |
Bin Liu, Professor, Department of Rheumatology, Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266000, Shandong Province, China. binliu72314@163.com |
| Key Words |
Primary biliary cholangitis; Exosomes; MiR-137; Natural killer cell; Granzyme B |
| Core Tip |
This study identifies elevated exosomal miR-137-3p in primary biliary cholangitis plasma as a key driver of natural killer cell hyperactivation. Mechanistically, miR-137-3p directly targets and inhibits nuclear factor of activated T cell 1, leading to upregulation of the activation marker CD16 and enhanced secretion of the cytotoxic molecule granzyme B. These findings define miR-137-3p as a novel diagnostic biomarker and suggest that targeting the miR-137-3p/nuclear factor of activated T cell 1 axis could be a promising therapeutic strategy for primary biliary cholangitis by alleviating natural killer cell-mediated bile duct injury. |
| Publish Date |
2026-06-26 09:50 |
| Citation |
Yang YF, Liu QX, Su WH, Zang B, Liu BQ, Zhao CY, Han YB, Liu LW, Leung PSC, Liu B. Plasma exosomal miR-137 activates natural killer cells in primary biliary cholangitis by targeting NFATC1. World J Hepatol 2026; 18(6): 116738
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i6/116738.htm |
| DOI |
https://doi.org/10.4254/wjh.116738 |
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