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Articles Published Processes
10/29/2026 7:19:29 AM | Browse: 2 | Download: 0
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Received |
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2025-11-20 05:37 |
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Peer-Review Started |
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2025-11-20 06:24 |
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First Decision by Editorial Office Director |
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2025-12-05 07:13 |
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Return for Revision |
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2025-12-05 07:13 |
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Revised |
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2025-12-05 08:07 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-19 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-19 06:36 |
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Articles in Press |
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2026-01-19 06:36 |
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Edit the Manuscript by Language Editor |
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2026-01-22 03:58 |
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Typeset the Manuscript |
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2026-09-20 03:38 |
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Publish the Manuscript Online |
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2026-10-29 07:19 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Opinion Review |
| Article Title |
Microbial dial: How the gut microbiome tunes the severity of autism spectrum disorder
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Takahiko Nagamine |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Takahiko Nagamine, MD, PhD, Professor, Psychiatric Internal Medicine, Sunlight Brain Research Center, 4-13-18 Jiyugaoka, Hofu 7470066, Yamaguchi, Japan. anagamine@yahoo.co.jp |
| Key Words |
Autism spectrum disorder; Gut microbiota; Monozygotic twins; Porphyromonas; Microbiome-gut-brain axis |
| Core Tip |
This study uses monozygotic twins to decouple genetic factors from gut microbiome influences on the severity of autism spectrum disorder (ASD). Despite identical genomes, twins with higher symptom severity exhibited distinct microbial community structures, functional metabolic deficits, and enrichment of the pro-inflammatory Porphyromonas. These findings support that the microbiome is a primary driver of phenotypic heterogeneity in ASD. Although limited by a small, correlational sample, the study provides a critical foundation for identifying microbiome-based therapeutic targets. Collectively, the evidence reinforces the concept that while host genetics predispose individuals to ASD, the gut microbiome dictates the specific intensity of behavioral manifestations. |
| Publish Date |
2026-10-29 07:19 |
| Citation |
Nagamine T. Microbial dial: How the gut microbiome tunes the severity of autism spectrum disorder. World J Psychiatry 2026; 16(11): 116755
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| URL |
https://www.wjgnet.com/2220-3206/full/v16/i11/116755.htm |
| DOI |
https://doi.org/10.5498/wjp.116755 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
