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Articles Published Processes
5/14/2026 9:17:09 AM | Browse: 4 | Download: 12
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Received |
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2025-11-20 08:52 |
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Peer-Review Started |
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2025-11-20 09:08 |
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First Decision by Editorial Office Director |
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2025-12-11 08:21 |
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Return for Revision |
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2025-12-11 08:21 |
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Revised |
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2025-12-18 13:36 |
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Publication Fee Transferred |
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2025-12-22 07:37 |
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Second Decision by Editor |
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2026-02-05 02:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-05 07:22 |
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Articles in Press |
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2026-02-05 07:22 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-24 09:33 |
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Publish the Manuscript Online |
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2026-05-14 09:17 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Severe hepatic steatosis as a protective prognostic factor in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Han Wang, Zhen-Ying Cao, Chun-Yan Xia, Xia Sheng, Yun Zhao, Hong-Zhen Chen, Wen-Ming Cong, Miao-Xia He and Hui Dong |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Noncommunicable Chronic Diseases-National Science and Technology Major Project |
No. 2023ZD0500100 |
| Shanghai Leading Talent Program of Eastern Talent Plan |
No. BJWS2024084 |
| Municipal Hospital Clinical Technology Promotion and Management Optimization Project by Shanghai Shenkang Hospital Development Center |
No. SHDC22023208 |
| Shanghai Science and Technology Innovation Action Plan-Medical Innovation Research Project |
No. 22Y11909100 |
| Naval Medical University Basic Medical Research Project |
No. 2023NQ095 |
| Take-off Project Talent Program of EHBH |
No. TF2024XSJJ02 |
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| Corresponding Author |
Hui Dong, Associate Faculty, Associate Professor, PhD, Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, No. 225 Changhai Road, Yangpu District, Shanghai 200438, China. huidongwh@126.com |
| Key Words |
Combined hepatocellular-cholangiocarcinoma; Mixed hepatocellular-cholangiocarcinoma; Hepatic steatosis; Hepatocellular steatosis; Liver steatosis; Fatty liver disease; Pathological assessment; Alcohol-related liver disease; Metabolic dysfunction-associated steatotic liver disease |
| Core Tip |
This retrospective multicenter study investigated the prognostic influence of hepatic steatosis in patients with combined hepatocellular-cholangiocarcinoma (cHCC-CCA). Severe hepatic steatosis was associated with a favorable prognosis in cHCC-CCA patients. This protective effect was particularly significant in preventing early recurrence and was more pronounced among non-cirrhotic patients. We propose that the evaluation of hepatic steatosis be incorporated into the routine pathological diagnosis of cHCC-CCA to optimize postoperative management for this tumor entity. |
| Publish Date |
2026-05-14 09:17 |
| Citation |
Wang H, Cao ZY, Xia CY, Sheng X, Zhao Y, Chen HZ, Cong WM, He MX, Dong H. Severe hepatic steatosis as a protective prognostic factor in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study. World J Gastrointest Oncol 2026; 18(5): 116764 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i5/116764.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i5.116764 |
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