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Articles Published Processes
3/15/2026 6:13:26 AM | Browse: 14 | Download: 40
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Received |
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2025-11-20 05:48 |
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Peer-Review Started |
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2025-11-20 06:25 |
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First Decision by Editorial Office Director |
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2025-11-26 09:24 |
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Return for Revision |
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2025-11-26 09:24 |
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Revised |
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2025-12-03 17:19 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-19 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-19 08:08 |
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Articles in Press |
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2026-01-19 08:08 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-28 06:46 |
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Publish the Manuscript Online |
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2026-03-15 06:13 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Minireviews |
| Article Title |
Unconventional mechanisms of resveratrol in atherosclerosis prevention and management
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Nadim Chaarani, Riyad Mroweh, Razan Moghnieh, Mohammad Kheir Chahine, Hassan Zaiter, Saleh-Yezan Abdulaal, Nazih Obeid, Mohamad Tlais, Joy Raheb, Hadi Farhat and Razan Abdulaal |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mohamad Tlais, Faculty of Medicine and Medical Sciences, University of Balamand, Hazmieh, Beirut 1100, Dekwaneh, Lebanon. mmtlaiss22@gmail.com |
| Key Words |
Resveratrol; Atherosclerosis; Endothelial dysfunction; Foam cells; Inflammation; Gut microbiota |
| Core Tip |
Resveratrol (RES) is a dietary polyphenol with pleiotropic anti-atherosclerotic actions that extend beyond conventional lipid lowering and antioxidant effects. This review synthesizes experimental evidence showing how RES stabilizes the endothelial barrier, remodels gut microbiota and bile acid metabolism, inhibits transforming growth factor–extracellular signal-regulated kinase signaling, modulates connexin 43 and phosphatase and actin regulator-1, and suppresses proinflammatory cytokine and smooth muscle cell migration pathways. By mapping these unconventional molecular targets, we highlight RES as a multi-target candidate for preventing plaque formation and promoting vascular homeostasis. |
| Publish Date |
2026-03-15 06:13 |
| Citation |
Chaarani N, Mroweh R, Moghnieh R, Kheir Chahine M, Zaiter H, Abdulaal SY, Obeid N, Tlais M, Raheb J, Farhat H, Abdulaal R. Unconventional mechanisms of resveratrol in atherosclerosis prevention and management. World J Exp Med 2026; 16(1): 116771 |
| URL |
https://www.wjgnet.com/2220-315x/full/v16/i1/116771.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v16.i1.116771 |
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