| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Diagnostic value of serum chitinase-3-like protein 1 for liver fibrosis/cirrhosis and hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hai-Ying Zhang, Run-Ling Zhang, Yu-Yuan Jia, Yan Liu, Ling Zhu, Feng Liu and Hui-Ying Rao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Program of China |
2022YFA1303804 |
|
| Corresponding Author |
Hui-Ying Rao, Professor, Peking University People's Hospital, Peking University Hepatology Institute, Infectious Disease and Hepatology Center of Peking University People's Hospital, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis, Peking University People's Hospital, Peking University Hepatology Institute, Infectious Disease and Hepatology Center of Peking University People's Hospital, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis, No. 133, Fuchengmennei Street, Xicheng District, Beijing 100044, China. rao.huiying@163.com |
| Key Words |
Chitinase-3-like protein 1; Viral hepatitis; Non-viral hepatitis; Liver cirrhosis; Hepatocellular carcinoma |
| Core Tip |
Serum chitinase-3-like protein 1 (CHI3L1) demonstrates robust diagnostic performance for liver cirrhosis [area under the receiver operating characteristic curve (AUC) = 0.874], hepatocellular carcinoma (HCC; AUC = 0.858) and HCC recurrence (AUC = 0.723) in liver disease patient cohorts. CHI3L1 exhibits positive correlations with liver stiffness measurement and the fibrosis-4 index, effectively differentiates fibrosis grades F3 and F4, and emerged as a reliable non-invasive biomarker for liver disease stratification, treatment monitoring and prognosis prediction, with superior performance than single traditional indices. |
| Publish Date |
2026-04-08 07:28 |
| Citation |
Zhang HY, Zhang RL, Jia YY, Liu Y, Zhu L, Liu F, Rao HY. Diagnostic value of serum chitinase-3-like protein 1 for liver fibrosis/cirrhosis and hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(4): 116821 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i4/116821.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i4.116821 |
