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Articles Published Processes
6/9/2026 9:23:58 AM | Browse: 0 | Download: 0
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Received |
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2025-11-24 11:05 |
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Peer-Review Started |
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2025-11-24 11:06 |
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First Decision by Editorial Office Director |
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2025-12-09 06:59 |
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Return for Revision |
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2025-12-09 06:59 |
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Revised |
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2025-12-21 08:31 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-06 02:48 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-06 07:09 |
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Articles in Press |
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2026-01-06 07:09 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-11 09:15 |
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Publish the Manuscript Online |
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2026-06-09 09:23 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Translational implications of the MAZ/UHRF1/ECRG4 axis in metastatic colorectal carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Eric Michael Kunz, Russell James Schoeller III, Joseph Patrick Carroll and Brandon Lucke-Wold |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Eric Michael Kunz, Doctorate Student, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, Miami, FL 33199, United States. ekunz005@med.fiu.edu |
| Key Words |
Colorectal neoplasms; Neoplasm metastasis; Myc-associated zinc finger protein; Esophageal cancer-related gene 4 protein; DNA methylation; Epithelial-mesenchymal transition; Transcription factors; Tumor suppressor genes |
| Core Tip |
This manuscript identifies a novel metastatic signaling cascade in colorectal cancer in which myc-associated zinc finger protein (MAZ) transcriptionally activates the epigenetic regulator ubiquitin-like with PHD and RING finger domains 1 (UHRF1), leading to hypermethylation and silencing of the tumor suppressor esophageal cancer-related gene 4 (ECRG4). This MAZ/UHRF1/ECRG4 axis drives epithelial–mesenchymal transition, invasion, and metastasis. Targeting MAZ or UHRF1—or restoring ECRG4 expression—may offer a promising epigenetic therapeutic strategy for metastatic colorectal carcinoma. |
| Publish Date |
2026-06-09 09:23 |
| Citation |
Kunz EM, Schoeller III RJ, Carroll JP, Lucke-Wold B. Translational implications of the MAZ/UHRF1/ECRG4 axis in metastatic colorectal carcinoma. World J Gastrointest Oncol 2026; 18(6): 116858
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i6/116858.htm |
| DOI |
https://doi.org/10.4251/wjgo.v18.i6.116858 |
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