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Articles Published Processes
8/5/2026 7:53:12 AM | Browse: 4 | Download: 47
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Received |
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2025-11-24 03:56 |
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Peer-Review Started |
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2025-11-25 00:35 |
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First Decision by Editorial Office Director |
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2026-01-22 07:34 |
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Return for Revision |
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2026-01-22 07:34 |
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Revised |
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2026-01-24 07:23 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-05 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-05 12:59 |
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Articles in Press |
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2026-03-05 12:59 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-22 08:44 |
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Publish the Manuscript Online |
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2026-08-05 07:53 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Editorial |
| Article Title |
Intercellular adhesion molecule-1 rs5498 in North India: Genetic spark for diabetic retinopathy inflammasome, not yet a clinical beacon
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yi Luo, Shun-Ping Zhou and Rong Guo |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the foundation of Yangpu District Health Commission |
No. YPM202415 |
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| Corresponding Author |
Rong Guo, Associate Professor, Department of Cardiology, Yangpu Hospital, Tongji University School of Medicine, No. 450 Tengyue Road, Shanghai 200090, China. 09_doctorguo@tongji.edu.cn |
| Key Words |
Intercellular adhesion molecule-1 rs5498; Diabetic retinopathy; Genetic association; North-Indian population; Genetic spark |
| Core Tip |
For the first time, the intercellular adhesion molecule-1 rs5498 GG genotype has been linked to an increased risk of diabetic retinopathy in Northern Indians, highlighting the inflammatory genetic architecture of this sight-threatening complication. However, the modest effect size, uncorrected statistical significance, absence of allele-specific expression data, and pronounced inter-ethnic heterogeneity observed in meta-analysis mandate large-scale prospective cohorts, functional validation through Clustered Regularly Interspaced Short Palindromic Repeats-based cellular assays, and multi-omic integration before this variant can be considered for clinical risk stratification or precision prevention strategies. |
| Publish Date |
2026-08-05 07:53 |
| Citation |
Luo Y, Zhou SP, Guo R. Intercellular adhesion molecule-1 rs5498 in North India: Genetic spark for diabetic retinopathy inflammasome, not yet a clinical beacon. World J Diabetes 2026; 17(8): 116870
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| URL |
https://www.wjgnet.com/1948-9358/full/v17/i8/116870.htm |
| DOI |
https://doi.org/10.4239/wjd.116870 |
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